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Article
Discontinuing therapy in childhood acute lymphoblastic leukemia treated with a chemoimmunotherapy protocol
We examined the results of discontinuing therapy in Japanese children with acute lymphoblastic leukemia. Of the 209 patients in the chemoimmunotherapy study, 120 (57.4%) had all chemotherapy stopped after 3 ye...
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Article
Cellular immunosuppression in children with acute lymphoblastic leukemia: Effect of consolidation chemotherapy
The present study was designed to evaluate the chemotherapy-induced cellular immunosuppression in 20 children with acute lymphoblastic leukemia (ALL) in remission and receiving maintenance chemotherapy. Periph...
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Article
Low R-wave amplitude in the right precordial leads in children with symptomatic doxorubicin cardiomyopathy
Electrocardiographic (ECG) findings were studied in four patients with doxorubicin cardiomyopathy. In all patients with congestive heart failure (CHF), the ECGs had a low R-wave and low R/S ratio in lead V1. Our ...
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Article
Intracellular cytokine profile of T cells from children with acute lymphoblastic leukemia
Purpose: During an ongoing immune response, cytokines produced by T helper types 1 (Th1) and 2 (Th2) together with T cytotoxic types 1 (Tc1) and 2 (Tc2) are critical to the effectiveness of that response. Dysreg...
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Article
Transient renal tubular acidosis in a neonate following transplacental acetazolamide
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Article
Role of Ca2+ in the Intracellular Signaling Pathway of Anti-IgM—Induced Apoptosis in the Human B-Cell Line, MBC-1, Established from Burkitt Lymphoma
The role of Ca2+ in the intracellular signal transduction process that causes antibody-induced apoptotic cell death in B-cells is not completely understood. We previously established a B-cell line (MBC-1) from a ...
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Article
Outcome After Relapse in Childhood Acute Lymphoblastic Leukemia
Among 157 children with acute lymphoblastic leukemia (ALL) who experienced relapse at 54 institutes participating in the Japan Association of Childhood Leukemia Study, we analyzed the outcomes after relapse in...
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Article
Systemic Heterogeneity of Endothelial Function after Kawasaki Diseases
Coronary arteritis associated with Kawasaki disease (KD) raises concern about the premature development of arteriosclerosis. Accordingly, we investigated endothelial function in the epicardial, resistance CAs,...
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Article
Clinical and Genetic Characteristics of Japanese Burkitt Lymphomas with or without Leukemic Presentation
To clarify the clinical and genetic features of Burkitt lymphoma with or without leukemic presentation, we have conducted clinical, cytogenetic, and genetic studies. Of 40 Japanese patients with Burkitt lympho...
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Article
Clinical significance of minimal residual disease in childhood acute myeloid leukemia
Many studies have assessed the clinical significance of the detection of minimal residual disease (MRD) in acute leukemia.Thus far, many studies have suggested that MRD detection to evaluate the response to ch...
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Article
False-Positive Plasma (1↙3)-β-D-Glucan Test following Immunoglobulin Product Replacement in an Adult Bone Marrow Recipient
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Article
Fever as a risk factor causing delayed elimination of methotrexate in pediatric patients receiving high doses of cancer chemotherapy
Delayed elimination of methotrexate (MTX) has been reported to be caused by a number of factors. In order to identify these causes, we retrospectively investigated the risk factors for delayed elimination in p...
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Article
Pediatric Cardiac Remodeling After Cardiac Resynchronization Therapy
A 1.8-year-old male required a conventional DDD pacemaker for an atrioventricular block after congenital heart surgery. Five years later, heart failure due to left ventricular (LV) dyssynchrony progressed and ...
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Article
Open AccessEmergence of physiological rhythmicity in term and preterm neonates in a neonatal intensive care unit
Biological rhythmicity, particularly circadian rhythmicity, is considered to be a key mechanism in the maintenance of physiological function. Very little is known, however, about biological rhythmicity pattern...
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Article
Open AccessCerebral oxygenation responses during kangaroo care in low birth weight infants
Kangaroo care (KC) has been widely using to improve the care of low birth weight infants. However, very little is known about cerebral hemodynamics responses in low birth weight infants during KC intervention....
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Article
Alternative Fas-mediated cell death pathway is dependent on the different cleavage patterns of procaspase-8
It has been reported that mitochondria-independent or mitochondria-dependent (type I/II) Fas signaling pathways in leukemia cells depend on the amount of active caspase-8. However, Bid molecules, which could n...
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Article
Postnatal Course of Hypoplastic Left Heart Complex and Restrictive Foramen Ovale
Hypoplastic left heart complex is a cardiac malformation at the mildest end of the spectrum of hypoplastic left heart syndrome. Recently, biventricular repair was proposed for such patients without retrograde ...
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Article
Immunohistochemical Localization of Manserin, a Novel Neuropeptide Derived from Secretogranin II, in Rat Adrenal Gland, and its Upregulation by Physical Stress
We recently identified a novel 40-amino acid neuropeptide designated manserin from the rat brain (Yajima in NeuroReport 15: 1755–1759, 2004). Manserin is highly expressed in pituitary and hypothalamic nuclei, ...
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Article
Flow cytometric analysis of de novo acute myeloid leukemia in childhood: report from the Japanese Pediatric Leukemia/Lymphoma Study Group
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Article
Elevated Von Willebrand factor propeptide for the diagnosis of thrombotic microangiopathy and for predicting a poor outcome
Thrombotic microangiopathy (TMA) is associated with vascular endothelial cell injury and is sometimes linked with poor outcome. Von Willebrand factor (VWF) propeptide (VWFpp) is considered to be a marker of va...
