9 Result(s)
within
Yoshihiro Kokubo
Biomedicine
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Article
Sleep duration and atrial fibrillation risk in the context of predictive, preventive, and personalized medicine: the Suita Study and meta-analysis of prospective cohort studies
Short and long sleep durations are common behaviors that could predict several cardiovascular diseases. However, the association between sleep duration and atrial fibrillation (AF) risk is not well-established...
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Article
Open AccessGlobal strategies for non-communicable disease in terms of predictive, preventive and personalised medicine
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Article
Meta-analysis identifies common variants associated with body mass index in east Asians
**ao-Ou Shu and colleagues report a meta-analysis of genome-wide association studies for body mass index (BMI) in east Asians. They identify three new genetic loci associated with BMI.
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Article
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
Norihiro Kato and colleagues perform a meta-analysis of genome-wide association studies to identify common variants associated with blood pressure variation in east Asians. They identify five new genome-wide s...
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Article
Open AccessAssociations of impaired glucose metabolism and dyslipidemia with cardiovascular diseases: what have we learned from Japanese cohort studies for individualized prevention and treatment?
Metabolic disorder is a modifiable risk factor for cardiovascular diseases (CVD), and lifestyle modification is the key to improving metabolic disorder. Diabetes mellitus has been shown to be a risk factor for...
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Article
Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population
The deletion of thiazide-sensitive Na–Cl cotransporter (TSC, SLC12A3) causes Gitelman’s syndrome characterized by low blood pressure, while deletions of the WNK1 (PRKWNK1) and WNK4 (PRKWNK4) genes cause familial ...
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Article
An association analysis between ApoA1 polymorphisms and the high-density lipoprotein (HDL) cholesterol level and myocardial infarction (MI) in Japanese
Association studies were performed to confirm the effect of polymorphisms in apolipoprotein A1 (ApoA1) on the high-density lipoprotein cholesterol (HDL-C) level and the incidence of myocardial infarction (MI). A ...
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Article
A promoter variant of the ATP-binding cassette transporter A1 gene alters the HDL cholesterol level in the general Japanese population
To investigate the effects of polymorphisms in the ATP-binding cassette transporter A1 (ABCA1) gene on the high-density lipoprotein cholesterol (HDL-C) level and the incidence of myocardial infarction (MI), we pe...
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Article
Genetic variants in PCSK9 affect the cholesterol level in Japanese
Mutations in the proprotein convertase subtilisin/kexin 9 (PCSK9) gene have been reported in affected members of two families with autosomal dominant hypercholesterolemia. To investigate the effects of common var...
