1 Result(s)

Article

Synthesis of 2-Methyl 16-Membered Macrolide Derived from Tylosin

To improve the metabolic stability of a 16-membered macrolide, 2-methylated derivatives of desmycosin were synthesized. Among these derivatives, 2β-methyldesmycosin retained antibacterial activity and showed i...

Yuichi Terui, Kenji Kinoshita, Yoshie Kaneda, Toshi Akashi… in The Journal of Antibiotics (2006)