3 Result(s)

Article

TaqTth-hpRNA: a novel compact RNA-targeting tool for specific silencing of pathogenic mRNA

Pathogenic allele silencing is a promising treatment for genetic hereditary diseases. Here, we develop an RNA-cleaving tool, TaqTth-hpRNA, consisting of a small, chimeric TaqTth, and a hairpin RNA guiding prob...

Chong Xu, Jiyanuo Cao, Huanran Qiang, Yu Liu, Jialin Wu, Qiudan Luo… in Genome Biology (2024)

Article

A crowdsourcing approach for reusing and meta-analyzing gene expression data

Naisha Shah, Yongjian Guo, Katherine V Wendelsdorf, Yong Lu… in Nature Biotechnology (2016)

Article

DAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis

Due to the complex and distributed nature of biological research, our current biological knowledge is spread over many redundant annotation databases maintained by many independent groups. Analysts usually nee...

Brad T Sherman, Da Wei Huang, Qina Tan, Yongjian Guo, Stephan Bour… in BMC Bioinformatics (2007)