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  1. Article

    Open Access

    Inhibition of TRPV4 remodels single cell polarity and suppresses the metastasis of hepatocellular carcinoma

    Hepatocellular carcinoma (HCC) is a malignant tumor, frequently causing both intrahepatic and extrahepatic metastases. The overall prognosis of patients with metastatic HCC is poor. Recently, single-cell (sc) ...

    Jian Liu, Yongjian Guo, Ruitian Zhang, Ye Xu, Chengju Luo, Rui Wang… in Cell Death & Disease (2023)

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  2. Article

    Open Access

    Inhibition of CEMIP potentiates the effect of sorafenib on metastatic hepatocellular carcinoma by reducing the stiffness of lung metastases

    Hepatocellular carcinoma (HCC) with lung metastasis is associated with poor prognosis and poor therapeutic outcomes. Studies have demonstrated that stiffened stroma can promote metastasis in various tumors. Ho...

    Mingyu Liu, Lulu **e, Yuying Zhang, Jianning Chen, **ang Zhang… in Cell Death & Disease (2023)

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  3. Article

    Open Access

    LZ-101, a novel derivative of danofloxacin, induces mitochondrial apoptosis by stabilizing FOXO3a via blocking autophagy flux in NSCLC cells

    Non-small-cell lung carcinoma (NSCLC) continues to be a vital disease worldwide for its high incidence and consequent mortality rate. In this study, we investigated the anti-cancer effect of LZ-101, a new deri...

    Yongjian Guo, Yue Zhao, Yuxin Zhou, **aoqing Tang, Zhiyu Li… in Cell Death & Disease (2019)

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