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Article
Open AccessTaqTth-hpRNA: a novel compact RNA-targeting tool for specific silencing of pathogenic mRNA
Pathogenic allele silencing is a promising treatment for genetic hereditary diseases. Here, we develop an RNA-cleaving tool, TaqTth-hpRNA, consisting of a small, chimeric TaqTth, and a hairpin RNA guiding prob...
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Article
Open AccessTyrosine-kinase inhibitor combined with iodine-125 seed brachytherapy for hepatocellular carcinoma refractory to transarterial chemoembolization: a propensity-matched study
To investigate the efficacy and safety of tyrosine-kinase inhibitor (TKI) combined with iodine-125 seed brachytherapy (TKI-I) versus TKI alone for patients with hepatocellular carcinoma (HCC) refractory to tra...
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Article
Open AccessInhibition of TRPV4 remodels single cell polarity and suppresses the metastasis of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a malignant tumor, frequently causing both intrahepatic and extrahepatic metastases. The overall prognosis of patients with metastatic HCC is poor. Recently, single-cell (sc) ...
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Open AccessInhibition of CEMIP potentiates the effect of sorafenib on metastatic hepatocellular carcinoma by reducing the stiffness of lung metastases
Hepatocellular carcinoma (HCC) with lung metastasis is associated with poor prognosis and poor therapeutic outcomes. Studies have demonstrated that stiffened stroma can promote metastasis in various tumors. Ho...
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Open AccessLZ-101, a novel derivative of danofloxacin, induces mitochondrial apoptosis by stabilizing FOXO3a via blocking autophagy flux in NSCLC cells
Non-small-cell lung carcinoma (NSCLC) continues to be a vital disease worldwide for its high incidence and consequent mortality rate. In this study, we investigated the anti-cancer effect of LZ-101, a new deri...
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Article
Correlation between fusion hole morphology and weld penetration in TIG welding
One-side welding with back-formation technique is widely used in pressure vessels and the pressure pi** industry. Welders attach immense importance to the role of the fusion hole in one-side welding with bac...
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Article
Edible peanut worm (Sipunculus nudus) in the Beibu Gulf: Resource, aquaculture, ecological impact and counterplan
Sipunculus nudus is an important economic species because of its high nutritional and medicinal values. The exploitation and utilization of S. nudus primarily occur in the coastal...
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Open AccessA crowdsourcing approach for reusing and meta-analyzing gene expression data
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Open AccessCorrection: Corrigendum: An interactive web-based application for Comprehensive Analysis of RNAi-screen Data
Nature Communications 7: Article number: 10578 (2016); Published 23 February 2016; Updated 21 March 2016 The original version of this article contained an error in the spelling of the author Eugen Buehler, whi...
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Open AccessAn interactive web-based application for Comprehensive Analysis of RNAi-screen Data
RNAi screens are widely used in functional genomics. Although the screen data can be susceptible to a number of experimental biases, many of these can be corrected by computational analysis. For this purpose, ...
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Article
Open AccessDAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis
Due to the complex and distributed nature of biological research, our current biological knowledge is spread over many redundant annotation databases maintained by many independent groups. Analysts usually nee...
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Article
Open AccessThe distribution of SNPs in human gene regulatory regions
As a result of high-throughput genoty** methods, millions of human genetic variants have been reported in recent years. To efficiently identify those with significant biological functions, a practical strate...