66 Result(s)

Article

Global transcriptome analysis reveals resistance genes in the early response of common bean (Phaseolus vulgaris L.) to Colletotrichum lindemuthianum

Disease can drastically impair common bean (Phaseolus vulgaris L.) production. Anthracnose, caused by the fungal pathogen Colletotrichum lindemuthianum (Sacc. and Magnus) Briosi and Cavara, is one of the diseases...

Yujie Chang, Yonghui Liu, Lanfen Wang, Shumin Wang, **g Wu in BMC Genomics (2024)

Article

Fumarate induces LncRNA-MIR4435-2HG to regulate glutamine metabolism remodeling and promote the development of FH-deficient renal cell carcinoma

Fumarate hydratase (FH) deficient renal cell carcinoma (RCC) is a type of tumor with definite metabolic disorder, but the mechanism of metabolic remodeling is still unclear. LncRNA was reported to closely corr...

Liangsong Zhu, Yilun Hong, Ziran Zhu, Jiwei Huang, Jianfeng Wang… in Cell Death & Disease (2024)

Article

Transport and inhibition mechanism for VMAT2-mediated synaptic vesicle loading of monoamines

Monoamine neurotransmitters such as serotonin and dopamine are loaded by vesicular monoamine transporter 2 (VMAT2) into synaptic vesicles for storage and subsequent release in neurons. Impaired VMAT2 function ...

Yuwei Wang, Pei Zhang, Yulin Chao, Zhini Zhu, Chuanhui Yang, Zixuan Zhou… in Cell Research (2024)

Article

Genome-wide identification and expression analysis of the GASA gene family in Chinese cabbage (Brassica rapa L. ssp. pekinensis)

The Gibberellic Acid-Stimulated Arabidopsis (GASA) gene family is widely involved in the regulation of plant growth, development, and stress response. However, information on the GASA gene family has not been rep...

Bingxin Sun, **anlei Zhao, Jiahui Gao, Jie Li, Yue **n, Yonghui Zhao… in BMC Genomics (2023)

Article

Innovative strategy for the conservation of a millennial mausoleum from biodeterioration through artificial light management

Artificial lights can cause critical microbial biodeterioration of heritage monuments by promoting the outbreak of phototrophic microbiomes when they are used for touristic viewing. Here, with the ultimate aim...

Yuanyuan Bao, Yan Ma, Wen**g Liu, **n Li, Yonghui Li… in npj Biofilms and Microbiomes (2023)

Article

Spatial Metabolomics Reveals the Multifaceted Nature of Lamprey Buccal Gland and Its Diverse Mechanisms for Blood-Feeding

Lampreys are blood-sucking vampires in marine environments. From a survival perspective, it is expected that the lamprey buccal gland exhibits a repository of pharmacologically active components to modulate th...

Meng Gou, Xuyuan Duan, Jun Li, Yaocen Wang, Qingwei Li, Yue Pang… in Communications Biology (2023)

Article

Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure

Acute liver failure (ALF) is a severe life-threatening disease associated with the disorder of the gut-liver axis. However, the cellular characteristics of ALF in the gut and related therapeutic targets remain...

Jie Yin, Ziming Zhao, Jianzheng Huang, Yang **ao, Mewlude Rehmutulla… in Cell Discovery (2023)

Article

Co-expression module analysis reveals high expression homogeneity for both coding and non-coding genes in sepsis

Sepsis is a life-threatening condition characterized by a harmful host response to infection with organ dysfunction. Annually about 20 million people are dead owing to sepsis and its mortality rates is as high...

**aojun Liu, Chengying Hong, Yichun Jiang, Wei Li, Youlian Chen, Yonghui Ma… in BMC Genomics (2023)

Article

Discovery of an OTUD3 inhibitor for the treatment of non-small cell lung cancer

The ubiquitin-proteasome system (UPS) controls protein turnover, and its dysfunction contributes to human diseases including cancer. Deubiquitinating enzymes (DUBs) remove ubiquitin from proteins to maintain t...

Yonghui Zhang, Tongde Du, Na Liu, Juan Wang, Lingqiang Zhang… in Cell Death & Disease (2023)

Article

Dual role of PID1 in regulating apoptosis induced by distinct anticancer-agents through AKT/Raf-1-dependent pathway in hepatocellular carcinoma

The treatment outcome of hepatocellular carcinoma (HCC) is severely hampered due to its etiology, and thus in depth understanding of the genetic mechanisms underlying response of HCC to various anticancer agen...

Jian Yang, Senlin Li, Jialuo He, Qianqian Xu, Mengyuan **e, Ci Yang… in Cell Death Discovery (2023)

Article

A human antibody potently neutralizes RSV by targeting the conserved hydrophobic region of prefusion F

Respiratory syncytial virus (RSV) continues to pose serious threats to pediatric populations due to the lack of a vaccine and effective antiviral drugs. RSV fusion (F) glycoprotein mediates viral-host membrane...

Chunyan Yi, Caixia Su, **aoyu Sun, **ao Lu, Chuanya Si… in Science China Life Sciences (2023)

Article

Use of mouse primary epidermal organoids for USA300 infection modeling and drug screening

Skin infections caused by drug-resistant Staphylococcus aureus occur at high rates nationwide. Mouse primary epidermal organoids (mPEOs) possess stratified histological and morphological characteristics of epider...

**aorui **e, Xuebo Tong, Zhihong Li, Quan Cheng, **aowei Wang… in Cell Death & Disease (2023)

Article

eSMC: a statistical model to infer admixture events from individual genomics data

Inferring historical population admixture events yield essential insights in understanding a species demographic history. Methods are available to infer admixture events in demographic history with extant gene...

Yonghui Wang, Zicheng Zhao, **nyao Miao, Yinan Wang, **aobo Qian… in BMC Genomics (2022)

Article

Author Correction: Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors

Qian Xu, Chunyan Wu, Qi Zhu, Renyuan Gao, Jianquan Lu… in Nature Aging (2022)

Article

Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2

Frequent outbreaks of coronaviruses underscore the need for antivirals and vaccines that can counter a broad range of coronavirus types. We isolated a human antibody named 76E1 from a COVID-19 convalescent pat...

**aoyu Sun, Chunyan Yi, Yuanfei Zhu, Longfei Ding, Shuai **a… in Nature Microbiology (2022)

Article

Platform for isolation and characterization of SARS-CoV-2 variants enables rapid characterization of Omicron in Australia

Genetically distinct variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged since the start of the COVID-19 pandemic. Over this period, we developed a rapid platform (R-20) for v...

Anupriya Aggarwal, Alberto Ospina Stella, Gregory Walker… in Nature Microbiology (2022)