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Article
Open AccessHippocampal Mrp8/14 signaling plays a critical role in the manifestation of depressive-like behaviors in mice
Depression is one of the most common mental disorders characterized mainly by low mood and loss of interest or pleasure. About a third of patients with depression do not respond to classic antidepressant treat...
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Article
Open AccessAntidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance
Abundant reports indicated that depression was often comorbid with type 2 diabetes and even metabolic syndrome. Considering they might share common biological origins, it was tentatively attributed to the chro...
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Article
TNFα mediates stress-induced depression by upregulating indoleamine 2,3-dioxygenase in a mouse model of unpredictable chronic mild stress
Depression is often preceded by exposure to stressful life events. Chronic stress causes perturbations in the immune system, and up-regulates production of proinflammatory cytokines, which has been proposed to...
