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Article
Open AccessAiouea padiformis extract exhibits anti-inflammatory effects by inhibiting the ATPase activity of NLRP3
Inflammation is implicated as a cause in many diseases. Most of the anti-inflammatory agents in use are synthetic and there is an unmet need for natural substance-derived anti-inflammatory agents with minimal ...
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Article
Open AccessClinical significance of lactate clearance in patients with cardiogenic shock: results from the RESCUE registry
Limited data are available on the clinical significance of lactate clearance (LC) in patients with cardiogenic shock (CS). This study investigated the prognostic role of LC in CS patients.
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Article
Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h
Haematopoietic stem and progenitor cells (HSPCs) have been the focus of developmental and regenerative studies, yet our understanding of the signalling events regulating their specification remains incomplete....
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Article
Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis
Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by homozygous or compound heterozygous gain-of-function mutations in MEFV, which encodes pyrin, an inflammasome protein. Heterozygous carri...
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Article
Open AccessFimasartan versus perindopril with and without diuretics in the treatment of elderly patients with essential hypertension (Fimasartan in the Senior Subjects (FITNESS)): study protocol for a randomized controlled trial
Hypertension is an important risk factor for cardiovascular disease, even in the elderly. Fimasartan is a new non-peptide angiotensin II receptor blocker with a selective type I receptor blocking effect. The o...
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Article
Open AccessNovel Genomic and Evolutionary Insight of WRKY Transcription Factors in Plant Lineage
The evolutionarily conserved WRKY transcription factor (TF) regulates different aspects of gene expression in plants, and modulates growth, development, as well as biotic and abiotic stress responses. Therefor...
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Article
Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS
Gain-of-function mutations in the gene encoding pyrin result in spontaneous autoinflammatory disease. Chae and colleagues detail a mechanism involving RhoA signaling that controls pyrin activity.
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Article
Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease
Ivona Aksentijevich and colleagues identify heterozygous loss-of-function mutations in TNFAIP3 (encoding A20) in six unrelated families with early-onset systemic inflammation. Affected individuals exhibit increas...
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Article
Pulse wave velocity is more closely associated with cardiovascular risk than augmentation index in the relatively low-risk population
Pulse wave velocity (PWV) and augmentation index (AI) are both indirect indicators of arterial stiffness, which is an independent predictor of morbidity and mortality in cardiovascular diseases. The aim of thi...
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Article
Antioxidative role of selenoprotein W in oxidant-induced mouse embryonic neuronal cell death
It has been reported that selenoprotein W (SelW) mRNA is highly expressed in the develo** central nerve system of rats, and its expression is maintained until the early postnatal stage. We here found that Se...
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Article
Agrobacterium-mediated genetic transformation of Perilla frutescens
A reproducible plant regeneration and an Agrobacterium tumefaciens-mediated genetic transformation protocol were developed for Perilla frutescens (perilla). The largest number of adventitious shoots were induced ...
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Article
Studies on protoplast formation and regeneration ofGanoderma lucidum
To obtain a new strain ofGanoderma lucidum by protoplast fusion technique, its protoplast formation and regeneration were studied. Several factors affecting the protoplast formation and regeneration were investig...
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Article
Studies on constituents of Korean basidiomycetes (L)
To find antitumor metabolites in Korean basidiomycetes, the shake-cultured mycelia of eight of the higher fungi were extracted with hot water and the extracts, after being partially purified, were subjected toin ...
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Article
Studies on the constituents and culture of Korean basidiomycetes
To develop potent antitumor polysaccharides from higher fungi of Korea the alcohol precipitated polysaccharides, which were obtained from hot water extracts of shake-cultured mycelia of eight species of basidi...
