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Article
Intermedin (adrenomedullin 2) promotes breast cancer metastasis via Src/c-Myc-mediated ribosome production and protein translation
Breast cancer is the most frequently diagnosed cancer and is the leading cause of cancer-associated mortality in women worldwide. Intermedin (IMD, also known as Adrenomedullin 2, ADM2) is an endogenous peptide...
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Article
Open AccessIntermedin facilitates hepatocellular carcinoma cell survival and invasion via ERK1/2-EGR1/DDIT3 signaling cascade
As one of the most malignant cancer types, hepatocellular carcinoma (HCC) is highly invasive and capable of metastasizing to distant organs. Intermedin (IMD), an endogenous peptide belonging to the calcitonin ...
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Article
Open AccessSunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence
Sunitinib, a receptor tyrosine kinase (RTK) inhibitor that targets multiple receptors such as vascular endothelial growth factor receptors (VEGFRs), was approved for cancer treatment in 2006. However, it was u...
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Article
Pure laparoscopic right hepatectomy of living donor is feasible and safe: a preliminary comparative study in China
The adoption of laparoscopic techniques for living donor major hepatectomy has been controversial issue. The aim of this study is to present the preliminary experience of laparoscopic right hepatectomy in China.
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Article
Open AccessIntermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses
Sepsis is a life-threatening condition caused by dysregulated host responses to infection. Widespread vascular hyperpermeability and a “cytokine storm” are two pathophysiological hallmarks of sepsis. Here, we ...
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Article
Open AccessOutcomes following laparoscopic versus open major hepatectomy for hepatocellular carcinoma in patients with cirrhosis: a propensity score-matched analysis
Laparoscopic major hepatectomy (LMH) for hepatocellular carcinoma (HCC) in patients with cirrhosis remains controversial due to limited reports in the literature. This study analyzed the perioperative and onco...
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Article
Safety and effectiveness of day-surgery laparoscopic cholecystectomy is still uncertain: meta-analysis of eight randomized controlled trials based on GRADE approach
Currently, there is no consensus on whether laparoscopic cholecystectomy (LC) performed as day-surgery is safe and effective and can be considered as the standard for the management of symptomatic gallbladder ...
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Article
Open AccessThe “inherent vice” in the anti-angiogenic theory may cause the highly metastatic cancer to spread more aggressively
Although anti-angiogenic (AA) therapy is widely used in clinical practice, it is often challenged by insufficient efficacy and intrinsic resistance. Some studies have reported that AA therapy can even increase...
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Article
Open AccessUpper abdominal shape as a risk factor of extended operation time and severe postoperative complications in HCC hepatectomy through subcostal incision
Subcostal incision is the most widely used approach in open surgery for patients with hepatocellular carcinoma (HCC). Body shape is recognised to be a factor influencing the difficulty of surgery; however, the...
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Article
Letter regarding Shen et al. entitled “The APE1 Asp148Glu polymorphism and colorectal cancer susceptibility: a meta-analysis”
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Article
Selective oxidation of methane and carbon deposition over Fe2O3/Ce1−x Zr x O2 oxides
A series of Fe2O3/Al2O3, Fe2O3/CeO2, Ce0.7Zr0.3O2, and Fe2O3/Ce1−x Zr x O2 (x = 0.1–0.4) oxides was prepared and their physicochemical features were inves...
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Article
Methodological remarks concerning the recent meta-analysis on CYP1A1 polymorphisms-smoking interaction and hepatocellular carcinoma risk
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Article
Higher Tacrolimus Blood Concentration Is Related to Hyperlipidemia in Living Donor Liver Transplantation Recipients
The arrival of tacrolimus has drastically improved AALDLT recipients’ survival. However, little data of tacrolimus have been reported concerning its effects on lipid metabolism for AALDLT recipients.
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Article
RAD51 135G/C polymorphism and breast cancer risk: a meta-analysis from 21 studies
Growing evidence suggests that RAD51 plays a pivotal role in the repair of DNA double-strand breaks and the maintenance of genomic stability. A single nucleotide polymorphism, 135G/C, has been identified in the 5...
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Article
The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis
Emerging evidence has shown that miRNAs participate in human carcinogenesis as tumor suppressors or oncogenes. Single nucleotide polymorphism (SNP) which located in the pre-miRNA may affect the processing and ...
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Article
Photoinduced electron transfer between adamantanamine-(OCH2CH2) n -phenothiazine and mono-6-p-nitrobenzoyl-β-cyclodextrin
A series of adamantanamine-(OCH2CH2) n -phenothiazine (n = 0, 1, 2, 3) electron donors was synthesized. Photoinduced electron transfer was observed in the supramolecular complex ...
