14 Result(s)
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Author Correction: Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial
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Perioperative toripalimab and chemotherapy in locally advanced gastric or gastro-esophageal junction cancer: a randomized phase 2 trial
Perioperative chemotherapy is the standard treatment for locally advanced gastric or gastro-esophageal junction cancer, and the addition of programmed cell death 1 (PD-1) inhibitor is under investigation. In t...
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The Aging Biomarker Consortium represents a new era for aging research in China
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Open AccessNeoadjuvant adebrelimab in locally advanced resectable esophageal squamous cell carcinoma: a phase 1b trial
Overall survival (OS) benefits of neoadjuvant immunotherapy remain elusive in locally advanced esophageal squamous cell carcinomas (ESCC). Here, we reported the results of a phase 1b trial of neoadjuvant PD-L1...
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Open AccessHuman loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior
Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and depression. Here we studied the role of the serotonin 2C receptor (5-HT2CR) in weight regulation and behavior. Using exom...
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Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates
Human pluripotent stem-cell-derived islets (hPSC-islets) are a promising cell resource for diabetes treatment1,2. However, this therapeutic strategy has not been systematically assessed in large animal models phy...
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BRAF somatic mutation contributes to intrinsic epileptogenicity in pediatric brain tumors
Pediatric brain tumors are highly associated with epileptic seizures1. However, their epileptogenic mechanisms remain unclear. Here, we show that the oncogenic BRAF somatic mutation p.Val600Glu (V600E) in develop...
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Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease
Activation of microglia by classical inflammatory mediators can convert astrocytes into a neurotoxic A1 phenotype in a variety of neurological diseases1,2. Development of agents that could inhibit the formation o...
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Correction: Corrigendum: Sex-specific transcriptional signatures in human depression
Nat. Med. 23, 1102–1111 (2017); published online 21 August 2017; corrected after print 7 March 2018 In the version of this article initially published, the last name of author Andrew Kasarskis was misspelled a...
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Sex-specific transcriptional signatures in human depression
Brain-region-specific RNA-seq from humans with major depressive disorder reveals unique transcriptomic profiles in males and females, with little overlap.
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Thalamic miR-338-3p mediates auditory thalamocortical disruption and its late onset in models of 22q11.2 microdeletion
The thalamus-enriched microRNA miR-338-3p is depleted in mouse models of 22q11.2 deletion syndrome and in humans with schizophrenia, leading to a late-onset dysfunction of auditory thalamocortical synaptic tra...
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A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition
CRISPR–Cas9-mediated insertion of a naturally occurring benign mutation in blood cell progenitors from patients with sickle cell disease increases fetal hemoglobin expression to levels sufficient to ameliorate...
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GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
In Alzheimer's disease, increased MAOB activity in reactive astrocytes leads to enhanced GABA release, and blockage of this pathway ameliorates memory dysfunction in mouse models.
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Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission
Delivery of HIV-specific neutralizing antibodies by adeno-associated virus vectors—termed vectored immunoprophylaxis (VIP)—has been shown to protect mice or macaques from intravenous infection by HIV or SIV, r...
