70 Result(s)

Article

Long-term survivals of immune checkpoint inhibitors as neoadjuvant and adjuvant therapy in dMMR/MSI-H colorectal and gastric cancers

The long-term survival benefit of immune checkpoint inhibitors (ICIs) in neoadjuvant and adjuvant settings is unclear for colorectal cancers (CRC) and gastric cancers (GC) with deficiency of mismatch repair (d...

Zhenghang Wang, Siyuan Cheng, Yanhong Yao, Shengde Liu… in Cancer Immunology, Immunotherapy (2024)

Article

Prediction of TKI response in EGFR-mutant lung cancer patients-derived organoids using malignant pleural effusion

Patient-derived organoids (PDOs) are valuable in predicting response to cancer therapy. PDOs are ideal models for precision oncologists. However, their practical application in guiding timely clinical decision...

Sang-Hyun Lee, Kyuhwan Kim, Eunyoung Lee, Kyungmin Lee… in npj Precision Oncology (2024)

Article

Oral arsenic plus imatinib versus imatinib solely for newly diagnosed chronic myeloid leukemia: a randomized phase 3 trial with 5-year outcomes

The synergistic effects of combining arsenic compounds with imatinib against chronic myeloid leukemia (CML) have been established using in vitro data. We conducted a clinical trial to compare the efficacy of t...

Jie Tian, Yong-** Song, Gao-Chong Zhang… in Journal of Cancer Research and Clinical On… (2024)

Article

XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

Qiu-Zhong Pan, **g-**g Zhao, Liang Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Rapid development of double-hit mRNA antibody cocktail against orthopoxviruses

The Orthopoxvirus genus, especially variola virus (VARV), monkeypox virus (MPXV), remains a significant public health threat worldwide. The development of therapeutic antibodies against orthopoxviruses is largely...

Hang Chi, Suo-Qun Zhao, Ru-Yi Chen… in Signal Transduction and Targeted Therapy (2024)

Article

Identification macrophage signatures in prostate cancer by single-cell sequencing and machine learning

The tumor microenvironment (TME) encompasses a variety of cells that influence immune responses and tumor growth, with tumor-associated macrophages (TAM) being a crucial component of the TME. TAM can guide pro...

Zhen Kang, Yu-Xuan Zhao, Ren Shun Qian Qiu… in Cancer Immunology, Immunotherapy (2024)

Article

Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)

A lasting imbalance between fatty acid synthesis and consumption leads to non-alcoholic fatty liver disease (NAFLD), coupled with hepatitis and insulin resistance. Yet the details of the underlying mechanisms ...

Lei Zhang, Jiabing Chen, **aoying Yang… in Signal Transduction and Targeted Therapy (2024)

Article

NUDT21 interacts with NDUFS2 to activate the PI3K/AKT pathway and promotes pancreatic cancer pathogenesis

NUDT21 (Nudix Hydrolase 21) has been shown to play an essential role in multiple biological processes. Pancreatic adenocarcinoma (PAAD) is one of the most fatal cancers in the world. However, the biological fu...

**ao-Dong Huang, Yong-Wei Chen, Lv Tian… in Journal of Cancer Research and Clinical On… (2024)

Article

Correction: Effect of Helicobacter pylori eradication after subtotal gastrectomy on the survival rate of patients with gastric cancer: follow-up for up to 15 years

Yonghoon Choi, Nayoung Kim, Chang Yong Yun, Yoon ** Choi, Hyuk Yoon… in Gastric Cancer (2023)

Article

Characterization of mesenchymal stem cells in human fetal bone marrow by single-cell transcriptomic and functional analysis

Bone marrow mesenchymal stromal/stem cells (MSCs) are a heterogeneous population that can self-renew and generate stroma, cartilage, fat, and bone. Although a significant progress has been made toward recogniz...

** Zhang, Ji Dong, **aoying Fan, Jun Yong… in Signal Transduction and Targeted Therapy (2023)

Article

Signaling pathways in Parkinson’s disease: molecular mechanisms and therapeutic interventions

Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be related to environmental and genetic factors, an...

Xu Dong-Chen, Chen Yong, Xu Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang… in Signal Transduction and Targeted Therapy (2023)

Article

Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation

Excessive inflammatory responses contribute to the pathogenesis and lethality of highly pathogenic human coronaviruses, but the underlying mechanism remains unclear. In this study, the N proteins of highly pat...

Ting Gao, Lin Zhu, Hainan Liu, **aopeng Zhang… in Signal Transduction and Targeted Therapy (2022)

Article

Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1

Indoleamine 2,3-dioxygenase 1 (IDO1), the enzyme that catabolizes tryptophan (Trp) metabolism to promote regulatory T cells (Tregs) and suppress CD8⁺ T cells, is regulated by several intrinsic signaling pathways....

Fan Liang, Gui-Zhen Wang, Yan Wang… in Signal Transduction and Targeted Therapy (2022)

Article

Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

Azvudine (FNC) is a nucleoside analog that inhibits HIV-1 RNA-dependent RNA polymerase (RdRp). Recently, we discovered FNC an agent against SARS-CoV-2, and have taken it into Phase III trial for COVID-19 patie...

**-Lan Zhang, Yu-Huan Li, Lu-Lu Wang… in Signal Transduction and Targeted Therapy (2021)

Article

Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein

SARS-CoV-2 and SARS-CoV are genetically related coronavirus and share the same cellular receptor ACE2. By replacing the VSV glycoprotein with the spikes (S) of SARS-CoV-2 and SARS-CoV, we generated two replica...

Hongyue Li, Yuhang Zhang, Dong Li… in Signal Transduction and Targeted Therapy (2021)