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Article
Open AccessDifferential regulation of the water channel protein aquaporins in chondrocytes of human knee articular cartilage by aging
Knee cartilage is in an aqueous environment filled with synovial fluid consisting of water, various nutrients, and ions to maintain chondrocyte homeostasis. Aquaporins (AQPs) are water channel proteins that pl...
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Article
Open AccessMicrobiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells
Although functional interplay between intestinal microbiota and distant sites beyond the gut has been identified, the influence of microbiota-derived metabolites on hematopoietic stem cells (HSCs) remains uncl...
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Article
Open AccessOptical manipulation of a dielectric particle along polygonal closed-loop geometries within a single water droplet
We report a new method to optically manipulate a single dielectric particle along closed-loop polygonal trajectories by crossing a suite of all-fiber Bessel-like beams within a single water droplet. Exploiting...
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Article
Open AccessAtrogin1-induced loss of aquaporin 4 in myocytes leads to skeletal muscle atrophy
The water channel aquaporin 4 (AQP4) regulates the flux of water across the cell membrane, maintaining cellular homeostasis. Since AQP4 is enriched in the sarcolemma of skeletal muscle, a functional defect in ...
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Article
Mitigating biofouling with a vanillin coating on thin film composite reverse osmosis membranes
Several methods, such as pretreatment, membrane surface modification, feed water chlorination, and chemical cleaning, have recently been applied to control biofouling on reverse osmosis (RO) membranes—with lim...
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Article
Altered gene and protein expressions of vitamin D receptor in skeletal muscle in sarcopenic patients who sustained distal radius fractures
Despite the presence of vitamin D receptor (VDR) in skeletal muscle cells, the relationship between VDR expressions and muscle mass or function has not been well studied. The purpose of this study was to compa...
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Article
Open AccessLoss of PKM2 in Lgr5+ intestinal stem cells promotes colitis-associated colorectal cancer
The regulatory properties of pyruvate kinase M2 isoform (PKM2), the key glycolytic enzyme, influence altered energy metabolism including glycolysis in cancer. In this study, we found that PKM2 was highly expre...
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Article
Inverse agonist of ERRγ reduces cannabinoid receptor type 1-mediated induction of fibrinogen synthesis in mice with a high-fat diet-intoxicated liver
Upon liver intoxication with malnutrition or high-fat diet feeding, fibrinogen is synthesized by hepatocytes and secreted into the blood in human and mouse. Its primary function is to occlude blood vessels upo...
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Article
Open AccessHepatocyte toll-like receptor 4 mediates lipopolysaccharide-induced hepcidin expression
Hepcidin expression is induced by inflammatory molecules such as lipopolysaccharide (LPS) via a macrophage-mediated pathway. Although hepatocytes directly respond to LPS, the molecular mechanism underlying tol...
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Article
Open AccessThe resident pathobiont Staphylococcus xylosus in Nfkbiz-deficient skin accelerates spontaneous skin inflammation
IκBζ, which is encoded by the Nfkbiz gene, is a member of the nuclear IκB family of proteins that act as transcriptional regulators via association with NF-κB. Nfkbiz-deficient (Nfkbiz −/−
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Article
Open AccessOrphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression
Small heterodimer partner (SHP) is a transcriptional corepressor regulating diverse metabolic processes. Here, we show that SHP acts as an intrinsic negative regulator of iron homeostasis. SHP-deficient mice m...
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Article
Open AccessTherapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model
Human rhinovirus (HRV) is the most common viral infectious agent in humans and is the predominant cause of the common cold. There is a need for appropriate vaccines or therapeutic agents to treat HRV infection...
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Article
Open AccessHypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice
Obesity is associated with ageing and increased energy intake, while restriction of energy intake improves health and longevity in multiple organisms; the NAD+-dependent deacetylase sirtuin 1 (SIRT1) is implicate...
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Article
Luteolin mediates the antidepressant-like effects of Cirsium japonicum in mice, possibly through modulation of the GABAA receptor
Cirsium japonicum (CJ) has been shown to possess antidepressant-like properties. In the present study, we sought to identify which constituent of CJ might be responsible for its antidepressant ef...
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Article
The involvement of magnoflorine in the sedative and anxiolytic effects of Sinomeni Caulis et Rhizoma in mice
The present study seeks to evaluate the sedative and anxiolytic effects of the 70 % ethanol extract of Sinomeni Caulis et Rhizoma (SR). The extract was orally administered to mice at dosages of 25, 50, 100, 200 o...
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Article
The nonequilibrium work relation in small systems
We theoretically investigate the nonequilibrium work-relation of Jarzynski which is designed to provide equilibrium information on mesoscopic thermodynamic systems that have undergone an irreversible transform...
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Article
Oroxylin A improves attention deficit hyperactivity disorder-like behaviors in the spontaneously hypertensive rat and inhibits reuptake of dopamine in vitro
In previous studies we have demonstrated that the γ-aminobutryic acid-A (GABA-A) receptor antagonist oroxylin A has an awakening effect and it also represses ADHD-like behaviors (hyperactivity, impulsivity and...
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Article
Open AccessT lymphocytes derived from human cord blood provide effective antitumor immunotherapy against a human tumor
Although the graft-versus-tumor (GVT) effect of donor-derived T cells after allogeneic hematopoietic stem cell transplantation has been used as an effective adoptive immunotherapy, the antitumor effects of cor...
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Article
Is the anti-stress effect of vitamin C related to adrenal gland function in rat?
The aim of this study was to investigate whether vitamin C influences the stress response system of the adrenal gland. Adrenalectomized (ADX) rats and non-ADX rats were administered vitamin C and were subjecte...
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Article
Mechanism of apoptosis induced by apigenin in hepg2 human hepatoma cells: involvement of reactive oxygen species generated by NADPH oxidase
Although plant-derived flavonoids have been reported to have anti-cancer activities, the exact mechanism of these actions is not completely understood. In this study we investigated the role for reactive oxyge...
