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Article
Open AccessPutative ligand binding sites of two functionally characterized bark beetle odorant receptors
Bark beetles are major pests of conifer forests, and their behavior is primarily mediated via olfaction. Targeting the odorant receptors (ORs) may thus provide avenues towards improved pest control. Such an ap...
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Article
Open AccessEndogenous insensitivity to the Orco agonist VUAA1 reveals novel olfactory receptor complex properties in the specialist fly Mayetiola destructor
Insect olfactory receptors are routinely expressed in heterologous systems for functional characterisation. It was recently discovered that the essential olfactory receptor co-receptor (Orco) of the Hessian fly,
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Article
Open AccessA structural preview of aquaporin 8 via homology modeling of seven vertebrate isoforms
Aquaporins (AQPs) facilitate the passage of small neutral polar molecules across membranes of the cell. In animals there are four distinct AQP subfamilies, whereof AQP8 homologues constitute one of the smalles...
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Article
Open AccessSingle amino acid substitutions in the selectivity filter render NbXIP1;1α aquaporin water permeable
Aquaporins (AQPs) are integral membrane proteins that facilitate transport of water and/or other small neutral solutes across membranes in all forms of life. The X Intrinsic Proteins (XIPs) are the most recent...
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Article
Mutual adaptation of a membrane protein and its lipid bilayer during conformational changes
The structural elucidation of membrane proteins continues to gather pace, but we know little about their molecular interactions with the lipid environment or how they interact with the surrounding bilayer. Her...
