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Article
Open AccessA novel T cell-redirecting anti-GPRC5D × CD3 bispecific antibody with potent antitumor activity in multiple myeloma preclinical models
G-protein-coupled receptor class 5 member D (GPRC5D) is detected in malignant plasma cells in approximately 90% of patients diagnosed with multiple myeloma (MM). Here, we constructed BsAb5003, a novel humanize...
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Article
F-36316 A and B, novel vasoactive compounds, isolated from Incrucipulum sp. SANK 10414
In the course of our screening program for vasoactive compounds using co-culture assay of endothelial cells and fibroblast cells, potent activity was detected in the cultured broth of Incrucipulum sp. SANK 10414....
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Article
Vestaines, novel vasoactive compounds, isolated from Streptomyces sp. SANK 63697
We conducted a screening program for vasoactive compounds and detected a potent activity in the cultured broth of Streptomyces sp. SANK 63697. From the cultured broth, two active compounds, vestaine A1 and B1, we...
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Chapter and Conference Paper
In Vitro Analysis of the Interaction Between Human Intestinal Epithelial Cells and Macrophage-Like Cells
Intestinal epithelial cells interact with immune cells located in the intestinal epithelium via soluble factors, and the disordered cellular communication is known as one of the factors of intestinal inflammat...
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Chapter and Conference Paper
Dietary Taurine Attenuates Dextran Sulfate Sodium (DSS)-induced Experimental Colitis in Mice
Effects of dietary taurine on the experimental colitis induced by dextran sulfate sodium (DSS) were studied. C57BL/6 mice administrated taurine or placebo for 5 days were given 3% DSS to induce acute. The coli...
