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    Article

    The immune system of jawless vertebrates: insights into the prototype of the adaptive immune system

    Jawless vertebrates diverged from an ancestor of jawed vertebrates approximately 550 million years ago. They mount adaptive immune responses to repetitive antigenic challenges, despite lacking major histocompa...

    Yoichi Sutoh, Masanori Kasahara in Immunogenetics (2021)

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    Article

    Copy number and sequence variation of leucine-rich repeat modules suggests distinct functional constraints operating on variable lymphocyte receptors expressed by agnathan T cell-like and B cell-like lymphocytes

    Unlike jawed vertebrates that use T cell and B cell receptors for antigen recognition, jawless vertebrates represented by lampreys and hagfish use variable lymphocyte receptors (VLR) as antigen receptors. VLRs...

    Yoichi Sutoh, Masanori Kasahara in Immunogenetics (2014)

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    Article

    Comparative genomic analysis of the proteasome β5t subunit gene: implications for the origin and evolution of thymoproteasomes

    The thymoproteasome is a recently discovered, specialized form of 20S proteasomes expressed exclusively in the thymic cortex. Although the precise molecular mechanism by which the thymoproteasome exerts its fu...

    Yoichi Sutoh, Mizuho Kondo, Yuko Ohta, Tatsuya Ota, Utano Tomaru… in Immunogenetics (2012)