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Prof. Dr. Jan Klein (1936-2023)
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The immune system of jawless vertebrates: insights into the prototype of the adaptive immune system
Jawless vertebrates diverged from an ancestor of jawed vertebrates approximately 550 million years ago. They mount adaptive immune responses to repetitive antigenic challenges, despite lacking major histocompa...
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Author Correction: Elephant shark genome provides unique insights into gnathostome evolution
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Biology, evolution, and history of antigen processing and presentation: Immunogenetics special issue 2019
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Origin and evolution of the specialized forms of proteasomes involved in antigen presentation
Proteasomes are a multi-subunit protease complex that produces peptides bound by major histocompatibility complex (MHC) class I molecules. Phylogenetic studies indicate that two specialized forms of proteasome...
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Open AccessStructure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility
The MILL family, composed of MILL1 and MILL2, is a group of nonclassical MHC class I molecules that occur in some orders of mammals. It has been reported that mouse MILL2 is involved in wound healing; however,...
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Open AccessVisualising the dynamics of live pancreatic microtumours self-organised through cell-in-cell invasion
Pancreatic ductal adenocarcinoma (PDAC) reportedly progresses very rapidly through the initial carcinogenesis stages including DNA damage and disordered cell death. However, such oncogenic mechanisms are large...
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The immunoproteasome and thymoproteasome: functions, evolution and human disease
The basic principle of adaptive immunity is to strictly discriminate between self and non-self, and a central challenge to overcome is the enormous variety of pathogens that might be encountered. In cell-media...
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Open AccessThe TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice
Intestinal tumorigenesis is promoted by myeloid differentiation primary response gene 88 (MyD88) activation in response to the components of microbiota in Apc Min/+
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Open AccessDouble-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells
Triggering receptors expressed on myeloid cells (Trem) proteins are a family of cell surface receptors used to control innate immune responses such as proinflammatory cytokine production in mice. Trem genes be...
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Anchorage-Dependent Multicellular Aggregate Formation Induces CD44 High Cancer Stem Cell-Like Phenotypes in Adult T Cell Leukemia/Lymphoma Cells
Adult T cell leukemia/lymphoma (ATL) is a highly invasive and intractable T cell malignancy caused by human T cell leukemia virus-1 infection. Leukemia/lymphoma cells that have invaded the tissues exhibit a pr...
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Variable Lymphocyte Receptors: A Current Overview
Jawless vertebrates represented by lampreys and hagfish mount antigen-specific immune responses using variable lymphocyte receptors. These receptors generate diversity comparable to that of T-cell and B-cell r...
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Correction: Corrigendum: Elephant shark genome provides unique insights into gnathostome evolution
Nature 505, 174–179 (2014); doi:10.1038/nature12826 The ranges of accession numbers JW861113–JW881738 and KA353634–KA353668 (20,661 in total) cited in this Article include 3,630 sequences that were unrelated a...
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Venkatesh et al. reply
Replying to J. M. Dijkstra Nature511,http://dx.doi.org/10.1038/nature13446(2014)
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Copy number and sequence variation of leucine-rich repeat modules suggests distinct functional constraints operating on variable lymphocyte receptors expressed by agnathan T cell-like and B cell-like lymphocytes
Unlike jawed vertebrates that use T cell and B cell receptors for antigen recognition, jawless vertebrates represented by lampreys and hagfish use variable lymphocyte receptors (VLR) as antigen receptors. VLRs...
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Open AccessElephant shark genome provides unique insights into gnathostome evolution
The emergence of jawed vertebrates (gnathostomes) from jawless vertebrates was accompanied by major morphological and physiological innovations, such as hinged jaws, paired fins and immunoglobulin-based adapti...
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Thymoproteasome: Role in Thymic Selection and Clinical Significance as a Diagnostic Marker for Thymic Epithelial Tumors
The thymoproteasome is a specialized type of proteasomes expressed exclusively in the thymic cortex. It has a unique catalytic subunit β5t with unusual enzymatic activity. The thymoproteasome exhibits lower ch...
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Immunogenetics of the NKG2D ligand gene family
NKG2D ligands (NKG2DLs) are a group of major histocompatibility complex (MHC) class I-like molecules, the expression of which is induced by cellular stresses such as infection, tumorigenesis, heat shock, tissu...
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Comparative genomic analysis of the proteasome β5t subunit gene: implications for the origin and evolution of thymoproteasomes
The thymoproteasome is a recently discovered, specialized form of 20S proteasomes expressed exclusively in the thymic cortex. Although the precise molecular mechanism by which the thymoproteasome exerts its fu...
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Open AccessStromal cells help ATL cells to escape from apoptosis induced by histone deacetylase inhibitors
