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  1. Article

    Open Access

    Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer

    Ferroptosis is a new type of iron-dependent programmed cell death induced by lipid peroxidation. However, the underlying mechanisms and function in tumor therapy still remain undisclosed especially in post-tra...

    Ge Zhang, Wunan Mi, Chuyue Wang, Jiehan Li, Yizheng Zhang… in Cell Death Discovery (2023)

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  2. Article

    Open Access

    Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth

    Targeting AKT suppresses tumor growth through inducing apoptosis, however, during which whether other forms of cell death occurring is poorly understood.

    Yizheng Zhang, Chuchu Zhang, Jiehan Li, Meimei Jiang… in Cell Communication and Signaling (2022)

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  3. Article

    Open Access

    Targeting ERK induced cell death and p53/ROS-dependent protective autophagy in colorectal cancer

    In recent years, many studies have shown that autophagy plays a vital role in the resistance of tumor chemotherapy. However, the interaction between autophagy and cell death has not yet been clarified. In this...

    Wunan Mi, Chuyue Wang, Guang Luo, Jiehan Li, Yizheng Zhang… in Cell Death Discovery (2021)

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  4. Article

    Open Access

    SNP rs12982687 affects binding capacity of lncRNA UCA1 with miR-873-5p: involvement in smoking-triggered colorectal cancer progression

    This investigation was arranged to elucidate whether single nucleotide polymorphisms (SNPs) of lncRNA UCA1 was implicated in elevating colorectal cancer (CRC) risk by interacting with environmental exposures.

    Yang Fu, Yizheng Zhang, **yuan Cui, Ge Yang… in Cell Communication and Signaling (2020)

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  5. No Access

    Article

    Characterization of lipopolysaccharide transport protein complex

    Lipopolysaccharide (LPS) is an essential component of the outer membranes (OM) of most Gram-negative bacteria, which plays a crucial role in protection of the bacteria from toxic compounds and harsh conditions...

    Quanju **ang, Haiyan Wang, Zhongshan Wang… in Central European Journal of Biology (2014)

  6. No Access

    Article

    Expression of the Arabidopsis vacuolar H+-pyrophosphatase gene AVP1 in peanut to improve drought and salt tolerance

    The Arabidopsis gene AVP1 encodes an H+-pyrophosphatase that functions as a proton pump at the vacuolar membranes, generating a proton gradient across vacuolar membranes, which serves as the driving force for man...

    Hua Qin, Qiang Gu, Sundaram Kuppu, Li Sun, Xunlu Zhu… in Plant Biotechnology Reports (2013)

  7. No Access

    Article

    Identification and characterization of differentially expressed genes involved in pharmacological activities of roots of Panax notoginseng during plant growth

    Panax notoginseng is a highly valued Chinese medicinal herb. To understand the molecular mechanism of the much higher pharmacological activities of roots of 3-year-old plants over 1-year-...

    Fengmei He, Yong** Zhu, Yizheng Zhang in Plant Cell Reports (2008)