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    Article

    Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain

    Polycomb repressive complex 1 (PRC1) is an essential chromatin-modifying complex that monoubiquitinates histone H2A and is involved in maintaining the repressed chromatin state. Emerging evidence suggests PRC1...

    Shirish Shukla, Weijiang Ying, Felicia Gray, Yiwu Yao in Nature Chemical Biology (2021)

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    Open Access

    Unprecedented reactions: from epichlorohydrin to epoxyglycidyl substituted divinyl ether and its conversion into epoxyglycidyl propargyl ether

    The reaction of epichlorohydrin with concentrated sodium hydroxide in hexane under phase transfer conditions has surprisingly led to the formation of the symmetrical di(3-epoxyglycidyl-1-propenyl) ether 1 which c...

    Yiwu Yao, Zheng Li, Yatao Qiu, **hong Bai, **yue Su, Dayong Zhang in Scientific Reports (2015)