67 Result(s)
within
Yitong **e
Life Sciences
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Article
Association of birthweight and risk of incident dementia: a prospective cohort study
Given the epidemiological studies investigating the relationship between birthweight and dementia are limited. Our study aimed to explore the association between birthweight and the risk of dementia, cognitive...
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RIP3 orchestrates oxidative stress and pyroptosis in doxorubicin-induced cardiotoxicity through regulation of AKT/Nrf2 signaling cascade
This study was designed to explore the role of RIP3 in DOX-induced cardiotoxicity and its underlying molecular mechanisms. Our results demonstrate that RIP3 exacerbates DOX-induced cardiotoxicity through promo...
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Open AccessAlterations of the bile microbiome is associated with progression-free survival in pancreatic ductal adenocarcinoma patients
Patients with pancreatic ductal adenocarcinoma (PDAC) display an altered oral, gastrointestinal, and intra-pancreatic microbiome compared to healthy individuals. However, knowledge regarding the bile microbiom...
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Rapid and specific detection of Chinook salmon bafinivirus (CSBV) in flatfish using loop-mediated isothermal amplification (LAMP)
It is now understood that the flatfish farming industry faces significant threats from Chinook salmon bafinivirus (CSBV) induced hemorrhagic disease. Develo** a prompt and efficient diagnostic method is cruc...
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Antibiotic resistance, biofilm formation, and molecular epidemiology of Staphylococcus aureus in a tertiary hospital in **angyang, China
Staphylococcus aureus is a common clinical pathogen that causes various human infections. The aim of this study was to investigate the antibiotic susceptibility pattern, molecular epidemiological characteristics,...
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Open AccessTranscriptome and metabolome analyses reveal the regulatory role of MdPYL9 in drought resistance in apple
The mechanisms by which the apple MdPYL9 gene mediates the response to drought stress remain unclear. Here, transcriptome and metabolome analyses of apple plants under drought were used to investigate the mechani...
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Open AccessRNA methylation patterns, immune characteristics, and autophagy-related mechanisms mediated by N6-methyladenosine (m6A) regulatory factors in venous thromboembolism
Recent studies have found a link between deep vein thrombosis and inflammatory reactions. N6-methyladenosine (m6A), a crucial element in immunological regulation, is believed to contribute to the pathophysiolo...
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Open AccessDecoding epitranscriptomic regulation of viral infection: map** of RNA N6-methyladenosine by advanced sequencing technologies
Elucidating the intricate interactions between viral pathogens and host cellular machinery during infection is paramount for understanding pathogenic mechanisms and identifying potential therapeutic targets. T...
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Open AccessIntegrative physiological, metabolomic, and transcriptomic analysis reveals the drought responses of two apple rootstock cultivars
Drought is considered the main environmental factor restricting apple production and thus the development of the apple industry. Rootstocks play an important role in enhancing the drought tolerance of apple pl...
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Open AccessIGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development
IGF2BP3 functions as an RNA-binding protein (RBP) and plays a role in the posttranscriptional control of mRNA localization, stability, and translation. Its dysregulation is frequently associated with tumorigen...
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Open AccessPediococcus acidilactici reduces tau pathology and ameliorates behavioral deficits in models of neurodegenerative disorders
Alzheimer’s disease (AD), affecting many elders worldwide, is characterized by A-beta and tau-related cognitive decline. Accumulating evidence suggests that brain iron accumulation is an important characterist...
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Open AccessFpOGT is required for fungal growth, stress response, and virulence of Fusarium proliferatum by affecting the expression of glucokinase and other glucose metabolism-related genes
O-GlcNAcylation, an important post-translational modification catalyzed by O-GlcNAc transferase (OGT), plays critical roles in several biological processes. In this study, we present our findings on the functi...
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Article
Transcriptomic profiling of adding cobalt chloride to improve dendrobine-type total alkaloid production
Trichoderma longibrachiatum UN32 is known for its efficient production of dendrobine-type total alkaloids (DTTAs). This study aimed to determine the optimal medium composition for the UN32 strain using response s...
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A chaperone-like function of FUS ensures TAZ condensate dynamics and transcriptional activation
The Hippo pathway has important roles in organ development, tissue homeostasis and tumour growth. Its downstream effector TAZ is a transcriptional coactivator that promotes target gene expression through the f...
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Open AccessSpinal cord injury-induced gut dysbiosis influences neurological recovery partly through short-chain fatty acids
Spinal cord injury (SCI) can reshape gut microbial composition, significantly affecting clinical outcomes in SCI patients. However, mechanisms regarding gut–brain interactions and their clinical implications h...
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Open AccessPhosphorus-solubilizing bacteria improve the growth of Nicotiana benthamiana on lunar regolith simulant by dissociating insoluble inorganic phosphorus
In-situ utilization of lunar soil resources will effectively improve the self-sufficiency of bioregenerative life support systems for future lunar bases. Therefore, we have explored the microbiological method ...
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Nano-Fe promotes accumulation of phytoestrogens and volatile compounds in Trifolium pratense flowers
Nano-Fe, a novel and efficient fertilizer, is usually applied to accelerate the growth and development of plants and trigger the accumulation of secondary metabolites to promote plant resistance. It can also i...
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Mechanism of iron on the intestinal epithelium development in suckling piglets
This study aimed to investigate the mechanism of iron on intestinal epithelium development of suckling piglets. Compared with newborn piglets, 7-day-old and 21-day-old piglets showed changes in the morphology ...
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Open AccessScreening and optimisation of in vitro pollen germination medium for sweetpotato (Ipomoea batatas)
Sweetpotato is an important vegetable and food crop that is bred through sexual crosses and systematic selection. The use of in vitro germination of sweetpotato pollen to test its viability has important theor...
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Article
Deltex E3 ubiquitin ligase 4 promotes thyroid cancer progression through stearoyl-CoA desaturase 1
In this study, we aimed to explore the molecular role of Deltex E3 ubiquitin ligase 4 (DTX4) in thyroid cancer (TC) both in vitro and in vivo. The expression level of DTX4 in TC tissues was compared using The ...
