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Article
Open AccessTRAIP regulates replication fork recovery and progression via PCNA
PCNA is a central scaffold that coordinately assembles replication and repair machineries at DNA replication forks for faithful genome duplication. Here, we describe TRAIP (RNF206) as a novel PCNA-interacting ...
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Article
Open AccessChemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity
Wnt/β-catenin signaling regulates multiple biological processes and aberration of this pathway is frequently observed in human cancers. Previously, we uncovered NC043 as a small-molecule inhibitor of Wnt/β-cat...
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Article
Open AccessMetformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation
Out of the breast cancer subtypes, triple-negative breast cancer (TNBC) has the poorest prognosis without effective targeted therapies. Metformin, a first-line drug for type 2 diabetes mellitus, was demonstrat...
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Article
Open AccessManganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice
SLC39A14 (also known as ZIP14), a member of the SLC39A transmembrane metal transporter family, has been reported to mediate the cellular uptake of iron and zinc. Recently, however, mutations in the SLC39A14 gene ...
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Article
Open AccessRIP3 is an upregulator of aerobic metabolism and the enhanced respiration by necrosomal RIP3 feeds back on necrosome to promote necroptosis
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Article
Open AccessYL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells
Aberrant activation of signal transducer and activator of transcription 3 (STAT3) plays a critical role in the proliferation and survival of multiple myeloma. And inactivation of STAT3 is considered a promisin...
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Article
Open AccessHemi-methylated CpG sites connect Dnmt1-knockdown-induced and Tet1-induced DNA demethylation during somatic cell reprogramming
The relationship between active DNA demethylation induced by overexpressing Tet1 and passive DNA demethylation induced by suppressing Dnmt1 remains unclear. Here, we found that DNMT1 preferentially methylated, bu...
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Open AccessEfficient engulfment of necroptotic and pyroptotic cells by nonprofessional and professional phagocytes
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Open AccessLncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury
Ischemia-reperfusion (I/R) is a common pathology when the blood supply to an organ was disrupted and then restored. During the reperfusion process, inflammation and tissue injury were triggered, which were med...
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Article
Open AccessFate decision of satellite cell differentiation and self-renewal by miR-31-IL34 axis
Quiescent satellite cells (SCs) that are activated to produce numerous myoblasts underpin the complete healing of damaged skeletal muscle. How cell-autonomous regulatory mechanisms modulate the balance among c...
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Article
Open AccessFecal microbiota transplantation from patients with autoimmune encephalitis modulates Th17 response and relevant behaviors in mice
The significance of the microbiota-gut-brain axis has been increasingly recognized as a major modulator of autoimmunity. Here, we aim to characterize the gut microbiota of a large cohort of treatment-naïve anti-N
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Open AccessUSP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment
Previous studies have implicated an essential role for UHRF1-mediated histone H3 ubiquitination in recruiting DNMT1 to replication sites for DNA maintenance methylation during S phase of the cell cycle. Howeve...
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Article
Open AccessSensitivity and specificity of SARS-CoV-2 S1 subunit in COVID-19 serology assays
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Open AccessCross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans
Interspecies blastocyst complementation enables organ-specific enrichment of xenogeneic pluripotent stem cell (PSC) derivatives, which raises an intriguing possibility to generate functional human tissues/orga...
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Open AccessAuthor Correction: Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans
A Correction to this paper has been published: https://doi.org/10.1038/s41421-021-00251-8
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Open AccessCryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations
Substitution of lysine 36 with methionine in histone H3.3 (H3.3K36M) is an oncogenic mutation that inhibits SETD2-mediated histone H3K36 tri-methylation in tumors. To investigate how the oncohistone mutation a...
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Article
Open AccessLncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA
Granulosa cell (GC) is a critical somatic component of ovarian follicles to support oocyte development, while the regulatory role of long noncoding RNA (lncRNA) in GCs is largely unknown. Here, we identified a...
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Open AccessDownregulated developmental processes in the postnatal right ventricle under the influence of a volume overload
The molecular atlas of postnatal mouse ventricular development has been made available and cardiac regeneration is documented to be a downregulated process. The right ventricle (RV) differs from the left ventr...
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Article
Open AccessGeneration of human blastocyst-like structures from pluripotent stem cells
Human blastocysts are comprised of the first three cell lineages of the embryo: trophectoderm, epiblast and primitive endoderm, all of which are essential for early development and organ formation. However, du...
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Article
Open AccessDynamics of TCR repertoire and T cell function in COVID-19 convalescent individuals
SARS-CoV-2 outbreak has been declared by World Health Organization as a worldwide pandemic. However, there are many unknowns about the antigen-specific T-cell-mediated immune responses to SARS-CoV-2 infection....