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MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy
The pseudokinase mixed lineage kinase domain-like (MLKL) is an essential component of the activation of the necroptotic pathway. Emerging evidence suggests that MLKL plays a key role in liver disease. However,...
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Article
Open AccessImmunometabolism in cancer: basic mechanisms and new targeting strategy
Maturing immunometabolic research empowers immune regulation novel approaches. Progressive metabolic adaptation of tumor cells permits a thriving tumor microenvironment (TME) in which immune cells always lose ...
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Article
Open AccessNCAPD3 exerts tumor-promoting effects in prostatic cancer via dual impact on miR-30a-5p by STAT3-MALAT1 and MYC
Non-SMC condensin II complex subunit D3 (NCAPD3) is a subunit of the non-structural maintenance of chromosomes condensin II complex, which involves chromosome condensation and segregation during mitosis. NCAPD...
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Open AccessInhibition of the ILK-AKT pathway by upregulation of PARVB contributes to the cochlear cell death in Fascin2 gene knockout mice
The Fscn2 (Fascin2) gene encodes an actin cross-linking protein that is involved in the formation of hair cell stereocilia and retina structure. Mutations in Fscn2 gene have been linked to hearing impairment and ...
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Open AccessAuthor Correction: Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis
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Open AccessMetformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis
Given the rapidly aging population, aging-related diseases are becoming an excessive burden on the global healthcare system. Metformin has been shown to be beneficial to many age-related disorders, as well as ...
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Article
Open AccessHaspin balances the ratio of asymmetric cell division through Wnt5a and regulates cell fate decisions in mouse embryonic stem cells
Many different types of stem cells utilize asymmetric cell division (ACD) to produce two daughter cells with distinct fates. Haspin-catalyzed phosphorylation of histone H3 at Thr3 (H3T3ph) plays important role...
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Article
Open AccessEmerging roles of ferroptosis-related miRNAs in tumor metastasis
Ferroptosis, a novel mode of cell death dependent on iron and reactive oxygen species, has been extensively explored during malignant tumors metastasis. Ferroptosis can interact with multiple components of the...
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Article
Open AccessAminoprocalcitonin protects against hippocampal neuronal death via preserving oxidative phosphorylation in refractory status epilepticus
Refractory status epilepticus (RSE) is a neurological emergency where sustaining seizure causes severe neuronal death. Currently, there is no available neuroprotectant effective in RSE. Aminoprocalcitonin (NPC...
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Article
Histone demethylase KDM5B licenses macrophage-mediated inflammatory responses by repressing Nfkbia transcription
Macrophages play a critical role in the immune homeostasis and host defense against invading pathogens. However, uncontrolled activation of inflammatory macrophages leads to tissue injury and even fuels autoim...
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Article
Open AccessCorrection to: NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress
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Open AccessJMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a chronic disorder characterized by hyperproliferation of pulmonary arterial smooth muscle cells (PASMCs). JMJD1C, a member of the Jumonji domain containing C (JMJC) hi...
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Article
Open AccessCorrection to: LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury
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Open AccessNSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress
Doxorubicin (DOX) is a commonly used antitumor drug, but its application has been limited because of its strong cardiac damage. This study aims to explore the role of NSUN2 in DOX-induced heart injury. C57BL/6...
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Open AccessHuman-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest
Exploring the functions of human-specific genes (HSGs) is challenging due to the lack of a tractable genetic model system. Testosterone is essential for maintaining human spermatogenesis and fertility, but the...
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Article
Open AccessRBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator
The mechanisms by which the tumor behaviors of hepatocellular carcinoma (HCC) support growth and metastasis remain largely unknown, and it has become increasingly apparent that molecular dysregulation is of co...
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Open AccessGankyrin modulated non-small cell lung cancer progression via glycolysis metabolism in a YAP1-dependent manner
Non-small cell lung cancer (NSCLC) is highly malignant and heterogeneous form of lung cancer and involves various oncogene alterations. Glycolysis, an important step in tumor metabolism, is closely related to ...
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Article
YB-1 is a positive regulator of KLF5 transcription factor in basal-like breast cancer
Y-box binding protein 1 (YB-1) is a well-known oncogene highly expressed in various cancers, including basal-like breast cancer (BLBC). Beyond its role as a transcription factor, YB-1 is newly defined as an ep...
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Article
Open AccessSilencing of lncRNA MALAT1 facilitates erastin-induced ferroptosis in endometriosis through miR-145-5p/MUC1 signaling
Endometriosis is a chronic disorder characterized by the implantation of endometrial glands and stroma outside the uterus. However, the pathogenesis of endometriosis is still unclear. To date, there is no full...
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Open AccessICA69 aggravates ferroptosis causing septic cardiac dysfunction via STING trafficking
Previous studies have demonstrated that cardiomyocyte apoptosis, ferroptosis, and inflammation participate in the progress of sepsis-induced cardiomyopathy (SIC). Although Islet cell autoantigen 69 (ICA69) is ...