54 Result(s)

Article

Correction: NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation

Yuanbo Hu, Chenbin Chen, **nya Tong, Sian Chen, **an**g Hu… in Cell Death & Disease (2024)

Article

ADT-OH exhibits anti-metastatic activity on triple-negative breast cancer by combinatorial targeting of autophagy and mitochondrial fission

High basal autophagy and enhanced mitochondrial fission in triple-negative breast cancer (TNBC) cells support cell migration and promote plasticity of cancer cell metabolism. Here, we suggest a novel combinati...

Shihui Yu, Zhiting Cao, Fangfang Cai, Yingying Yao, **aoyao Chang… in Cell Death & Disease (2024)

Article

Coronin 2B deficiency induces nucleolar stress and neuronal apoptosis

In eukaryotes, the nucleolus is the critical non-membranous organelle within nuclei that is responsible for ribosomal DNA (rDNA) transcription and ribosome biogenesis. The transcription of rDNA, a rate-limitin...

Hongjiao Wu, Yujie Yang, Wanying Yi, Yue Qiu, Shuangshuang Ma… in Cell Death & Disease (2024)

Article

IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer

There is a paucity of comprehensive knowledge pertaining to the underlying mechanisms leading to gefitinib resistance in individuals diagnosed NSCLC harboring EGFR-sensitive mutations who inevitably develop re...

Hengxiao Lu, Jiangshan Ai, Yingying Zheng, Wolong Zhou… in Cell Death & Disease (2024)

Article

Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL

Necroptosis is a kind of programmed cell death that causes the release of damage-associated molecular patterns and inflammatory disease including skin inflammation. Activation of receptor-interacting serine/th...

**gyi Li, **ngfeng Liu, Yuanyuan Liu, Fangmin Huang, Jiankun Liang… in Cell Death & Disease (2024)

Article

Retraction Note: Periostin secreted by cancer-associated fibroblasts promotes cancer stemness in head and neck cancer by activating protein tyrosine kinase 7

Binbin Yu, Kailiu Wu, Xu Wang, Jianjun Zhang, Lizhen Wang… in Cell Death & Disease (2024)

Article

Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis

Endometriosis is a gynecological inflammatory disease that is linked with immune cells, specifically macrophages. IL-33 secreted from macrophages is known to accelerate the progression of endometriosis. The pe...

Qiong Wu, Zongwen Liang, **g Jiang, **aoming Feng, **ming Liu… in Cell Death & Disease (2023)

Article

Crotonylated BEX2 interacts with NDP52 and enhances mitophagy to modulate chemotherapeutic agent-induced apoptosis in non-small-cell lung cancer cells

Brain expressed X-linked gene 2 (BEX2) encoded protein was originally identified to promote transcription by interacting with several transcription factors in the DNA–binding complexes. Recently, BEX2 was found t...

Ning Mu, Yu Wang, **aopeng Li, Zhiyuan Du, Yingdi Wu, Min Su… in Cell Death & Disease (2023)

Article

PPM1K mediates metabolic disorder of branched-chain amino acid and regulates cerebral ischemia-reperfusion injury by activating ferroptosis in neurons

Ischemic stroke is a neurological disorder caused by vascular stenosis or occlusion, accounting for approximately 87% of strokes. Clinically, the most effective therapy for ischemic stroke is vascular recanali...

Tao Li, Lili Zhao, Ye Li, Meijuan Dang, Jialiang Lu, Ziwei Lu… in Cell Death & Disease (2023)

Article

TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway

T-LAK-originated protein kinase (TOPK), a dual specificity serine/threonine kinase, is up-regulated and related to poor prognosis in many types of cancers. Y-box binding protein 1 (YB1) is a DNA/RNA binding pr...

Wenjie Wu, Jialuo Xu, Dan Gao, Zhenliang **e, Wen**g Chen… in Cell Death & Disease (2023)

Article

Hepatocyte-specific TMEM16A deficiency alleviates hepatic ischemia/reperfusion injury via suppressing GPX4-mediated ferroptosis

Ischemia/reperfusion (I/R)-induced liver injury with severe cell death is a major complication of liver transplantation. Transmembrane member 16A (TMEM16A), a component of hepatocyte Ca²⁺-activated chloride chann...

Jiawei Guo, Zihao Song, Jie Yu, Chengyi Li, Chenchen **, Wei Duan… in Cell Death & Disease (2022)

Article

Oxidative degradation of dihydrofolate reductase increases CD38-mediated ferroptosis susceptibility

High expression of CD38 in tissues is a characteristic of aging, resulting in a decline in nicotinamide adenine dinucleotide (NAD) and increasing cellular reactive oxygen species (ROS). However, whether CD38 i...

Yingying Ma, Meiqi Yi, Weixuan Wang, **aohui Liu, Qingtao Wang… in Cell Death & Disease (2022)

Article

Inhibitory effect of the novel tyrosine kinase inhibitor DCC-2036 on triple-negative breast cancer stem cells through AXL-KLF5 positive feedback loop

Triple-negative breast cancer (TNBC), an aggressive histological subtype of breast cancer, exhibits a high risk of early recurrence rate and a poor prognosis, and it is primarily associated with the abundance ...

Yingying Shen, Qingyun Zhu, Maoyu **ao, Liyang Yin, Wenjie Feng… in Cell Death & Disease (2022)

Article

FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia

Hypoxic pulmonary hypertension (PH) is a progressive disease characterized by hyper-proliferation of pulmonary vascular cells including pulmonary artery smooth muscle cells (PASMCs) and can lead to right heart...

Ruxia Liu, Chunling Xu, Weilin Zhang, Yangpo Cao, **g**g Ye… in Cell Death & Disease (2022)

Article

Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression

Prostate cancer (PCa) is a malignant tumor that seriously threatens men’s health worldwide. Recently, stromal cells in the tumor microenvironment (TME) have been reported to contribute to the progression of PC...

Tianqi Wu, Wenfeng Wang, Guohai Shi, Mingang Hao, Yingying Wang… in Cell Death & Disease (2022)

Article

Systematic analyses identify the anti-fibrotic role of lncRNA TP53TG1 in IPF

Long non-coding RNA (lncRNA) was reported to be a critical regulator of cellular homeostasis, but poorly understood in idiopathic pulmonary fibrosis (IPF). Here, we systematically identified a crucial lncRNA, ...

Jian Sun, Yingying Guo, Tingting Chen, Tongzhu **, Lu Ma… in Cell Death & Disease (2022)

Article

DNAJC24 is a potential therapeutic target in hepatocellular carcinoma through affecting ammonia metabolism

Evolutionarily conserved heat shock proteins are involved in the heat shock response of cells in response to changes in the external environment. In normal tissues, heat shock proteins can help cells survive i...

Guangtao Li, Yuchao He, Hui Liu, Dongming Liu, Lu Chen, Yi Luo… in Cell Death & Disease (2022)

Article

Hypoxia-induced NFATc3 deSUMOylation enhances pancreatic carcinoma progression

The transcriptional regulator nuclear factor of activated T-cells, cytoplasmic 3 (NFATc3) is constitutively activated in several cancer types and plays important roles in cancer development and progression. He...

Yingying Tong, Zheng Zhang, Yurong Cheng, **g Yang, Cong Fan… in Cell Death & Disease (2022)

Article

Reticulon 2 promotes gastric cancer metastasis via activating endoplasmic reticulum Ca²⁺ efflux-mediated ERK signalling

Gastric cancer ranks fourth for mortality globally among various malignant tumours, and invasion and metastasis are the major reason leading to its poor prognosis. Recently, accumulating studies revealed the r...

Shushu Song, Bo Liu, **aoqing Zeng, Yingying Wu, Hao Chen, Hao Wu… in Cell Death & Disease (2022)

Article

LPS/Bcl3/YAP1 signaling promotes Sox9⁺HNF4α⁺ hepatocyte-mediated liver regeneration after hepatectomy

Recent reports have demonstrated that Sox9⁺HNF4α⁺ hepatocytes are involved in liver regeneration after chronic liver injury; however, little is known about the origin of Sox9⁺HNF4α⁺ hepatocytes and the regulatory...

Changchun Shao, Yingying **g, Shanmin Zhao, Xue Yang, Yiming Hu… in Cell Death & Disease (2022)