209 Result(s)

Article

Vitamin C inactivates c-Jun N-terminal kinase to stabilize heart and neural crest derivatives expressed 1 (Hand1) in regulating placentation and maintenance of pregnancy

Vitamin C (VC) serves as a pivotal nutrient for anti-oxidation process, metabolic responses, and stem cell differentiation. However, its precise contribution to placenta development and gestation remains obscu...

Haibin Zhu, Huan Luo, **aowei Wu, Hangyang Bao… in Cellular and Molecular Life Sciences (2024)

Article

Correction: NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation

Yuanbo Hu, Chenbin Chen, **nya Tong, Sian Chen, **an**g Hu… in Cell Death & Disease (2024)

Article

CCDC88C, an O-GalNAc glycosylation substrate of GALNT6, drives breast cancer metastasis by promoting c-JUN-mediated CEMIP transcription

Coiled-coil domain containing 88C (CCDC88C) is a component of non-canonical Wnt signaling, and its dysregulation causes colorectal cancer metastasis. Dysregulated expression of CCDC88C was observed in lymph no...

Boya Deng, Siyang Zhang, Yingying Zhou, Ting Sun, Ying Zhu… in Cancer Cell International (2024)

Article

ADT-OH exhibits anti-metastatic activity on triple-negative breast cancer by combinatorial targeting of autophagy and mitochondrial fission

High basal autophagy and enhanced mitochondrial fission in triple-negative breast cancer (TNBC) cells support cell migration and promote plasticity of cancer cell metabolism. Here, we suggest a novel combinati...

Shihui Yu, Zhiting Cao, Fangfang Cai, Yingying Yao, **aoyao Chang… in Cell Death & Disease (2024)

Article

Coronin 2B deficiency induces nucleolar stress and neuronal apoptosis

In eukaryotes, the nucleolus is the critical non-membranous organelle within nuclei that is responsible for ribosomal DNA (rDNA) transcription and ribosome biogenesis. The transcription of rDNA, a rate-limitin...

Hongjiao Wu, Yujie Yang, Wanying Yi, Yue Qiu, Shuangshuang Ma… in Cell Death & Disease (2024)

Article

IGFBP2/ITGA5 promotes gefitinib resistance via activating STAT3/CXCL1 axis in non-small cell lung cancer

There is a paucity of comprehensive knowledge pertaining to the underlying mechanisms leading to gefitinib resistance in individuals diagnosed NSCLC harboring EGFR-sensitive mutations who inevitably develop re...

Hengxiao Lu, Jiangshan Ai, Yingying Zheng, Wolong Zhou… in Cell Death & Disease (2024)

Article

Author Correction: RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

Zhentao Yang, Yan Wang, Yingying Zhang, **adi He, Chuan-Qi Zhong… in Nature Cell Biology (2024)

Article

Immunometabolism in cancer: basic mechanisms and new targeting strategy

Maturing immunometabolic research empowers immune regulation novel approaches. Progressive metabolic adaptation of tumor cells permits a thriving tumor microenvironment (TME) in which immune cells always lose ...

Ranran Su, Yingying Shao, Manru Huang, Donghui Liu, Haiyang Yu… in Cell Death Discovery (2024)

Article

Assessing the role of programmed cell death signatures and related gene TOP2A in progression and prognostic prediction of clear cell renal cell carcinoma

Kidney Clear Cell Carcinoma (KIRC), the predominant form of kidney cancer, exhibits a diverse therapeutic response to Immune Checkpoint Inhibitors (ICIs), highlighting the need for predictive models of ICI eff...

Qingshui Wang, Jiamin Liu, Ruiqiong Li, Simeng Wang, Yining Xu… in Cancer Cell International (2024)

Article

The m6A reader IGF2BP2 promotes esophageal cell carcinoma progression by enhancing EIF4A1 translation

Esophageal squamous cell carcinoma (ESCC) is one of most prevalent cancers worldwide, especially in China. Lacking in depth mechanism study, effective targets and therapeutics are desperately needed in the cli...

Yuan Li, Zhuya **ao, Yingying Wang, Daoming Zhang, Zuhua Chen in Cancer Cell International (2024)

Article

The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb

Rheb is a small G protein that functions as the direct activator of the mechanistic target of rapamycin complex 1 (mTORC1) to coordinate signaling cascades in response to nutrients and growth factors. Despite ...

Ran Feng, Feng Liu, Ruofei Li, Zhifen Zhou, Zhuoheng Lin, Song Lin… in Cell Research (2024)

Article

Mitochondrial (mt)DNA–cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis

Macrophage proinflammatory activation contributes to the pathology of severe acute pancreatitis (SAP) and, simultaneously, macrophage functional changes, and increased pyroptosis/necrosis can further exacerbat...

Yiqiu Peng, Yuxi Yang, Yingying Li, Tingjuan Shi… in Cellular & Molecular Biology Letters (2024)

Article

Continuous immunosuppression is required for suppressing immune responses to xenografts in non-human primate brains

Continuous immunosuppression has been widely used in xenografts into non-human primate brains. However, how immune responses change after transplantation in host brains under continuous immunosuppressive admin...

Su Feng, Ting Zhang, Zhengxiao He, Wenchang Zhang, Yingying Chen… in Cell Regeneration (2024)

Article

NCAPD3 exerts tumor-promoting effects in prostatic cancer via dual impact on miR-30a-5p by STAT3-MALAT1 and MYC

Non-SMC condensin II complex subunit D3 (NCAPD3) is a subunit of the non-structural maintenance of chromosomes condensin II complex, which involves chromosome condensation and segregation during mitosis. NCAPD...

Yi Zhang, Yingying Shao, Jia Ren, Yuanyuan Fang, Bolin Yang… in Cell Death Discovery (2024)

Article

Perspective view of allogeneic IgG tumor immunotherapy

Allogeneic tumors are eradicated by host immunity; however, it is unknown how it is initiated until the report in Nature by Yaron Carmi et al. in 2015. Currently, we know that allogeneic tumors are eradicated by ...

Ying Liu, Yuanyi Huang, Hong-Wei Cui, YingYing Wang, ZhaoWu Ma… in Cancer Cell International (2024)

Article

Metabolism of asparagine in the physiological state and cancer

Asparagine, an important amino acid in mammals, is produced in several organs and is widely used for the production of other nutrients such as glucose, proteins, lipids, and nucleotides. Asparagine has also be...

Qiong Yuan, Liyang Yin, Jun He, Qiting Zeng… in Cell Communication and Signaling (2024)

Article

Inhibition of the ILK-AKT pathway by upregulation of PARVB contributes to the cochlear cell death in Fascin2 gene knockout mice

The Fscn2 (Fascin2) gene encodes an actin cross-linking protein that is involved in the formation of hair cell stereocilia and retina structure. Mutations in Fscn2 gene have been linked to hearing impairment and ...

Rongrong Liu, Wen**g Shang, Yingying Liu, Yi **e, Jun Luan… in Cell Death Discovery (2024)

Article

Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL

Necroptosis is a kind of programmed cell death that causes the release of damage-associated molecular patterns and inflammatory disease including skin inflammation. Activation of receptor-interacting serine/th...

**gyi Li, **ngfeng Liu, Yuanyuan Liu, Fangmin Huang, Jiankun Liang… in Cell Death & Disease (2024)

Article

Integrated bioinformatics analysis of SEMA3C in tongue squamous cell carcinoma using machine-learning strategies

Tongue squamous cell carcinoma (TSCC) is an aggressive oral cancer with a high incidence of metastasis and poor prognosis. We aim to identify and verify potential biomarkers for TSCC using bioinformatics analy...

Huixin Dou, Can Song, **aoyan Wang, Zhien Feng, Yingying Su… in Cancer Cell International (2024)

Article

Characterization of Retinal VIP-Amacrine Cell Development During the Critical Period

Retinal vasoactive intestinal peptide amacrine cells (VIP-ACs) play an important role in various retinal light-mediated pathological processes related to different developmental ocular diseases and even mental...

Xuhong Zhang, **aoyu Wang, Yanqing Li… in Cellular and Molecular Neurobiology (2024)