111 Result(s)

Article

Establishment of customized mouse stem cell lines by sequential nuclear transfer

Therapeutic cloning, whereby embryonic stem cells (ESCs) are derived from nuclear transfer (NT) embryos, may play a major role in the new era of regenerative medicine. In this study we established forty nuclea...

Chunli Zhao, Ruqiang Yao, Jie Hao, Chenhui Ding, Yong Fan, **angpeng Dai… in Cell Research (2007)

Article

Gibberellin homeostasis and plant height control by EUI and a role for gibberellin in root gravity responses in rice

The rice Eui (E LONGATED U PPERMOST I NTERNODE) gene encodes a cytochrome P450 monooxygenase that deactivates bioactive gibberellins (GAs). In this study, we investigated controlled expression of the Eui gene a...

Yingying Zhang, Yongyou Zhu, Yu Peng, Dawei Yan, Qun Li, Jianjun Wang… in Cell Research (2008)

Article

L-glutamine provides acid resistance for Escherichia coli through enzymatic release of ammonia

Bacteria, exemplified by enteropathogenic Escherichia coli (E. coli), rely on elaborate acid resistance systems to survive acidic environment (such as the stomach). Comprehensive understanding of bacterial acid r...

Peilong Lu, Dan Ma, Yuling Chen, Yingying Guo, Guo-Qiang Chen… in Cell Research (2013)

Article

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

Mixed lineage kinase domain-like protein (Mlkl) was recently found to interact with receptor interacting protein 3 (Rip3) and to be essential for tumor necrosis factor (TNF)-induced programmed necrosis (necrop...

Jianfeng Wu, Zhe Huang, Junming Ren, Zhirong Zhang, Peng He, Yangxin Li… in Cell Research (2013)

Article

Electrophysiologist shows a cation channel function of MLKL

Whether mixed lineage kinase domain-like (MLKL) mediates necroptosis by forming ion channel, none-selective pore, or simply by disrupting plasma membrane is unclear. In a paper published in recent issue of Cell R...

Yingying Zhang, Jiahuai Han in Cell Research (2016)

Article

TRAIP regulates replication fork recovery and progression via PCNA

PCNA is a central scaffold that coordinately assembles replication and repair machineries at DNA replication forks for faithful genome duplication. Here, we describe TRAIP (RNF206) as a novel PCNA-interacting ...

Wanjuan Feng, Yingying Guo, Jun Huang, Yiqun Deng, Jianye Zang… in Cell Discovery (2016)

Article

Chemical biology reveals CARF as a positive regulator of canonical Wnt signaling by promoting TCF/β-catenin transcriptional activity

Wnt/β-catenin signaling regulates multiple biological processes and aberration of this pathway is frequently observed in human cancers. Previously, we uncovered NC043 as a small-molecule inhibitor of Wnt/β-cat...

**aoli He, Wenjuan Zhang, Chen Yan, Fen Nie, Chen Li, **aofen Liu… in Cell Discovery (2017)

Article

Metformin suppresses triple-negative breast cancer stem cells by targeting KLF5 for degradation

Out of the breast cancer subtypes, triple-negative breast cancer (TNBC) has the poorest prognosis without effective targeted therapies. Metformin, a first-line drug for type 2 diabetes mellitus, was demonstrat...

Peiguo Shi, Wen**g Liu, Tala, Haixia Wang, Fubing Li, Hailin Zhang… in Cell Discovery (2017)

Article

Keratin 23 promotes telomerase reverse transcriptase expression and human colorectal cancer growth

The overexpression of human telomerase reverse transcriptase (hTERT) has been associated with the proliferation and migration of colorectal cancer (CRC) cells. We investigated the roles of KRT23 and hTERT in p...

Ningning Zhang, Rui Zhang, Kun Zou, Wendan Yu, Wei Guo… in Cell Death & Disease (2017)

Article

Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice

SLC39A14 (also known as ZIP14), a member of the SLC39A transmembrane metal transporter family, has been reported to mediate the cellular uptake of iron and zinc. Recently, however, mutations in the SLC39A14 gene ...

Yongjuan **n, Hong Gao, Jia Wang, Yuzhen Qiang, Mustapha Umar Imam… in Cell Discovery (2017)

Article

Plasma membrane changes during programmed cell deaths

Ruptured and intact plasma membranes are classically considered as hallmarks of necrotic and apoptotic cell death, respectively. As such, apoptosis is usually considered a non-inflammatory process while necros...

Yingying Zhang, **n Chen, Cyril Gueydan, Jiahuai Han in Cell Research (2018)

Article

Anthelmintic niclosamide suppresses transcription of BCR-ABL fusion oncogene via disabling Sp1 and induces apoptosis in imatinib-resistant CML cells harboring T315I mutant

Tyrosine kinase BCR-ABL fusion protein is the driver in patients with chronic myeloid leukemia (CML). The gate-keeper mutation T315I is the most challenging mutant due to its resistance to most tyrosine kinase...

Bei **, Chengyan Wang, Yingying Shen, **gxuan Pan in Cell Death & Disease (2018)

Article

MicroRNA-379-5p is associated with biochemical premature ovarian insufficiency through PARP1 and XRCC6

Premature ovarian insufficiency (POI) imposes great challenges on women’s fertility and lifelong health. POI is highly heterogeneous and encompasses occult, biochemical, and overt stages. MicroRNAs (miRNAs) ar...

Yujie Dang, **aoyan Wang, Ya**g Hao, **nyue Zhang, Shidou Zhao… in Cell Death & Disease (2018)

Article

Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth

HSP60 is a mitochondrial localized quality control protein responsible for maintaining mitochondrial function. Although HSP60 is considered both a tumor suppressor and promoter in different types of cancer, the r...

Chao Zhou, Hongwei Sun, Chen Zheng, **g Gao, Qingzi Fu, Nianqi Hu… in Cell Death & Disease (2018)

Article

Molecular basis for CENP-N recognition of CENP-A nucleosome on the human kinetochore

Tian Tian, **aorun Li, Yingying Liu, Chengliang Wang, **ng Liu… in Cell Research (2018)

Article

RIP3 is an upregulator of aerobic metabolism and the enhanced respiration by necrosomal RIP3 feeds back on necrosome to promote necroptosis

**ngfeng Qiu, Yingying Zhang, Jiahuai Han in Cell Death & Differentiation (2018)

Article

PIWIL2 suppresses Siah2-mediated degradation of HDAC3 and facilitates CK2α-mediated HDAC3 phosphorylation

HDAC3 is involved in deacetylation of histone and non-histone proteins, having a key role in the regulation of gene transcription and also in the process of tumorgenesis. However, how HDAC3 is regulated in can...

Yingying Zhang, Xulei Zheng, Hao Tan, Yilu Lu, Dachang Tao… in Cell Death & Disease (2018)

Article

Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice

Tctn3 belongs to the Tectonic (Tctn) family and is a single-pass membrane protein localized at the transition zone of primary cilia as an important component of ciliopathy-related protein complexes. Previous s...

Bin Wang, Yingying Zhang, Hongli Dong, Siyi Gong, Bin Wei, Man Luo… in Cell Death & Disease (2018)

Article

Nogo-C regulates post myocardial infarction fibrosis through the interaction with ER Ca²⁺ leakage channel Sec61α in mouse hearts

Cardiac fibrosis is an independent risk factor for heart failure and even the leading cause of death in myocardial infarction patients. However, molecular mechanisms associated with the pathogenesis of cardiac...

Lin Weng, Shi Jia, Chunling Xu, **g**g Ye, Yangpo Cao… in Cell Death & Disease (2018)

Article

Decreased expression of ARHGAP15 promotes the development of colorectal cancer through PTEN/AKT/FOXO1 axis

Copious evidence demonstrates the crucial role of Rho GTPase-activating proteins in human malignancies. The downregulation of Rho GTPase-activating protein 15 (ARHGAP15), a Rac1-specific GAP, has been observed...

Shengli Pan, Yingying Deng, Jun Fu, Yuhao Zhang, Zhi** Zhang… in Cell Death & Disease (2018)