22 Result(s)

Article

RIP3 is an upregulator of aerobic metabolism and the enhanced respiration by necrosomal RIP3 feeds back on necrosome to promote necroptosis

**ngfeng Qiu, Yingying Zhang, Jiahuai Han in Cell Death & Differentiation (2018)

Article

YL064 directly inhibits STAT3 activity to induce apoptosis of multiple myeloma cells

Aberrant activation of signal transducer and activator of transcription 3 (STAT3) plays a critical role in the proliferation and survival of multiple myeloma. And inactivation of STAT3 is considered a promisin...

Yingying Wang, Linlin Wu, Haiyan Cai, Hu Lei, Chun-Min Ma, Li Yang… in Cell Death Discovery (2018)

Article

LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury

Ischemia-reperfusion (I/R) is a common pathology when the blood supply to an organ was disrupted and then restored. During the reperfusion process, inflammation and tissue injury were triggered, which were med...

Peixing Wan, Wenru Su, Yingying Zhang, Zhidong Li… in Cell Death & Differentiation (2020)

Article

Fate decision of satellite cell differentiation and self-renewal by miR-31-IL34 axis

Quiescent satellite cells (SCs) that are activated to produce numerous myoblasts underpin the complete healing of damaged skeletal muscle. How cell-autonomous regulatory mechanisms modulate the balance among c...

Yang Su, Yingying Yu, Chuncheng Liu, Yuying Zhang… in Cell Death & Differentiation (2020)

Article

Fecal microbiota transplantation from patients with autoimmune encephalitis modulates Th17 response and relevant behaviors in mice

The significance of the microbiota-gut-brain axis has been increasingly recognized as a major modulator of autoimmunity. Here, we aim to characterize the gut microbiota of a large cohort of treatment-naïve anti-N

Hao Chen, Zhaoyu Chen, Li** Shen, **uhua Wu, Xueying Ma… in Cell Death Discovery (2020)

Article

LncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA

Granulosa cell (GC) is a critical somatic component of ovarian follicles to support oocyte development, while the regulatory role of long noncoding RNA (lncRNA) in GCs is largely unknown. Here, we identified a...

Duan Li, **aoyan Wang, Guangyu Li, Yujie Dang, Shidou Zhao… in Cell Death Discovery (2021)

Article

Downregulated developmental processes in the postnatal right ventricle under the influence of a volume overload

The molecular atlas of postnatal mouse ventricular development has been made available and cardiac regeneration is documented to be a downregulated process. The right ventricle (RV) differs from the left ventr...

Chunxia Zhou, Sijuan Sun, Mengyu Hu, Yingying **ao, **afeng Yu… in Cell Death Discovery (2021)

Article

ICA69 aggravates ferroptosis causing septic cardiac dysfunction via STING trafficking

Previous studies have demonstrated that cardiomyocyte apoptosis, ferroptosis, and inflammation participate in the progress of sepsis-induced cardiomyopathy (SIC). Although Islet cell autoantigen 69 (ICA69) is ...

Chang Kong, Xuqing Ni, Yixiu Wang, Anqi Zhang, Yingying Zhang… in Cell Death Discovery (2022)

Article

Silencing of lncRNA MALAT1 facilitates erastin-induced ferroptosis in endometriosis through miR-145-5p/MUC1 signaling

Endometriosis is a chronic disorder characterized by the implantation of endometrial glands and stroma outside the uterus. However, the pathogenesis of endometriosis is still unclear. To date, there is no full...

Zongwen Liang, Qiong Wu, Honglin Wang, Jiahuan Tan, Han Wang… in Cell Death Discovery (2022)

Article

Gankyrin modulated non-small cell lung cancer progression via glycolysis metabolism in a YAP1-dependent manner

Non-small cell lung cancer (NSCLC) is highly malignant and heterogeneous form of lung cancer and involves various oncogene alterations. Glycolysis, an important step in tumor metabolism, is closely related to ...

Tong Yu, Yanyan Liu, Junwen Xue, **ang Sun, Di Zhu, Lu Ma… in Cell Death Discovery (2022)

Article

RBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator

The mechanisms by which the tumor behaviors of hepatocellular carcinoma (HCC) support growth and metastasis remain largely unknown, and it has become increasingly apparent that molecular dysregulation is of co...

Tao Guo, Ke You, ** Chen, Yuqi Sun, Ying Wu, ** Wu… in Cell Death Discovery (2022)

Article

Human-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest

Exploring the functions of human-specific genes (HSGs) is challenging due to the lack of a tractable genetic model system. Testosterone is essential for maintaining human spermatogenesis and fertility, but the...

Chao Li, Yuming Feng, Zhenxin Fu, Junjie Deng, Yue Gu, Hanben Wang… in Cell Death Discovery (2022)

Article

NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

Doxorubicin (DOX) is a commonly used antitumor drug, but its application has been limited because of its strong cardiac damage. This study aims to explore the role of NSUN2 in DOX-induced heart injury. C57BL/6...

Yi Wang, Yuxin Zan, Yingying Huang, **aoyun Peng, Shinan Ma, Ji Ren… in Cell Death Discovery (2023)

Article

Correction to: LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury

Peixing Wan, Wenru Su, Yingying Zhang, Zhidong Li… in Cell Death & Differentiation (2023)

Article

JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a chronic disorder characterized by hyperproliferation of pulmonary arterial smooth muscle cells (PASMCs). JMJD1C, a member of the Jumonji domain containing C (JMJC) hi...

Chen Zhang, Yue Sun, Yingying Guo, **g**g Xu, Haiyan Zhao in Cell Death Discovery (2023)

Article

Correction to: NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

Yi Wang, Yuxin Zan, Yingying Huang, **aoyun Peng, Shinan Ma, Ji Ren… in Cell Death Discovery (2023)

Article

Aminoprocalcitonin protects against hippocampal neuronal death via preserving oxidative phosphorylation in refractory status epilepticus

Refractory status epilepticus (RSE) is a neurological emergency where sustaining seizure causes severe neuronal death. Currently, there is no available neuroprotectant effective in RSE. Aminoprocalcitonin (NPC...

Changgeng Song, **g**g Zhao, Jianmin Hao, Dan Mi, Jiajia Zhang… in Cell Death Discovery (2023)

Article

Emerging roles of ferroptosis-related miRNAs in tumor metastasis

Ferroptosis, a novel mode of cell death dependent on iron and reactive oxygen species, has been extensively explored during malignant tumors metastasis. Ferroptosis can interact with multiple components of the...

Zhongyi Jiang, **g Zhou, Junqi Deng, Luohong Li, Ruifeng Wang… in Cell Death Discovery (2023)

Article

Haspin balances the ratio of asymmetric cell division through Wnt5a and regulates cell fate decisions in mouse embryonic stem cells

Many different types of stem cells utilize asymmetric cell division (ACD) to produce two daughter cells with distinct fates. Haspin-catalyzed phosphorylation of histone H3 at Thr3 (H3T3ph) plays important role...

Yingying Gao, Bin Ma, Yifan Li, **angyu Wu, Shifeng Zhao… in Cell Death Discovery (2023)

Article

Inhibition of the ILK-AKT pathway by upregulation of PARVB contributes to the cochlear cell death in Fascin2 gene knockout mice

The Fscn2 (Fascin2) gene encodes an actin cross-linking protein that is involved in the formation of hair cell stereocilia and retina structure. Mutations in Fscn2 gene have been linked to hearing impairment and ...

Rongrong Liu, Wen**g Shang, Yingying Liu, Yi **e, Jun Luan… in Cell Death Discovery (2024)