4,102 Result(s)
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Yingying **ao
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Article
AdipoRon Ameliorates Synaptic Dysfunction and Inhibits tau Hyperphosphorylation through the AdipoR/AMPK/mTOR Pathway in T2DM Mice
There is growing evidence showing that adiponectin (APN) can improve Alzheimer’s disease(AD)-like pathological changes by improving insulin resistance. However, the role of AdipoRon (an Adiponectin receptor ag...
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Open AccessPrioritizing drug targets in systemic lupus erythematosus from a genetic perspective: a druggable genome-wide Mendelian randomization study
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with an unsatisfactory state of treatment. We aim to explore novel targets for SLE from a genetic standpoint.
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Open AccessA novel deep-benthic sea cucumber species of Benthodytes (Holothuroidea, Elasipodida, Psychropotidae) and its comprehensive mitochondrial genome sequencing and evolutionary analysis
The holothurians, commonly known as sea cucumbers, are marine organisms that possess significant dietary, nutritional, and medicinal value. However, the National Center for Biotechnology Information (NCBI) cur...
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A fuzzy computational framework for dynamic multibody system considering structure damage based on information entropy
The present study proposes a new fuzzy finite element method for dynamic multibody interaction with consideration for structural damage. Here, fuzzy parameters are equivalently transformed into stochastic para...
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Open AccessCorrection: NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation
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Combining multimodal diffusion-weighted imaging and morphological parameters for detecting lymph node metastasis in cervical cancer
Accurate detection of lymph node metastasis (LNM) is crucial for determining the tumor stage, selecting optimal treatment, and estimating the prognosis for cervical cancer. This study aimed to assess the diagn...
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Open AccessMoSey1 regulates the unfolded protein response, appressorium development, and pathogenicity of Magnaporthe oryzae
Endoplasmic reticulum (ER) is an enclosed three-dimensional eukaryotic membrane network composed of flattened sacs. Fusion of homologous membranes to the ER membrane is essential for the maintenance of this ne...
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Open AccessRemote coupling of electrical and mechanical cues by diurnal photothermal irradiation synergistically promotes bone regeneration
Recapitulating the natural extracellular physical microenvironment has emerged as a promising method for tissue regeneration, as multiple physical interventions, including ultrasound, thermal and electrical th...
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A column-shared histogramming TDC with pixel-to-pixel coincidence detection and compact analog counters for Flash LiDAR sensor
This study presents a column-shared hTDC with pixel-to-pixel coincidence detection and compact analog pulse counters. The column-shared architecture allows the hTDC to have no large area consumption caused by ...
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Pathogenesis of cardiovascular diseases: effects of mitochondrial CF6 on endothelial cell function
Cardiovascular disease (CVD) stands as a predominant global cause of morbidity and mortality, necessitating effective and cost-efficient therapies for cardiovascular risk reduction. Mitochondrial coupling fact...
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Open AccessIdentification of Parkinson’s disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data
Parkinson’s disease (PD) is a serious neurodegenerative disorder marked by significant clinical and progression heterogeneity. This study aimed at addressing heterogeneity of PD through integrative analysis of...
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Effect of Bamboo Charcoal with Earthworms on the Form and Bioavailability of Heavy Metals in Steel Sludge
It is difficult to utilize steel mill sludge because of the high concentration of heavy metals included therein. To passivate the activity of heavy metals, reduce their toxicity, and create a new valuable prod...
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What influences parental burnout in parents of children with autism spectrum disorder in China? A qualitative study
Parental burnout is associated with decreased life satisfaction of family members, increased marital conflict, and poor prognosis of children with autism spectrum disorders. Alleviating parenting burnout in pa...
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The Cooling Effect of Plant Configuration on Urban Parks Green Space in Temperate Continental Climate Zones
In temperate continental climate zones with hot summers and significant diurnal temperature differences, the park green space construction is an effective way to increase park visitor comfort and mitigate urba...
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Open AccessCCDC88C, an O-GalNAc glycosylation substrate of GALNT6, drives breast cancer metastasis by promoting c-JUN-mediated CEMIP transcription
Coiled-coil domain containing 88C (CCDC88C) is a component of non-canonical Wnt signaling, and its dysregulation causes colorectal cancer metastasis. Dysregulated expression of CCDC88C was observed in lymph no...
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Open AccessIntegrative analysis of genomic and epigenomic regulation reveals miRNA mediated tumor heterogeneity and immune evasion in lower grade glioma
The expression dysregulation of microRNAs (miRNA) has been widely reported during cancer development, however, the underling mechanism remains largely unanswered. In the present work, we performed a systematic...
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Is the Homologous Recombination Repair Mutation Defined by a 15-Gene Panel Associated with the Prognosis of Epithelial Ovarian Cancer?
There is no consensus regarding the specific genes included in the homologous recombination repair (HRR) gene panel for identifying the HRR deficiency (HRD) status and predicting the prognosis of epithelial ov...
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Thermal conductivity and mechanical properties of fluorite-type porous (Ce0.2Zr0.2Ti0.2Sn0.2Ca0.2)O2-δ high-entropy ceramics
Thermal insulation materials must exhibit superior mechanical properties alongside exceptional thermal insulation conductivity. However, traditional porous ceramics often struggle to meet these dual requiremen...
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Microplastics supply contaminants in food chain: non-negligible threat to health safety
The occurrence of microplastics (MPs) and organic pollutants (OPs) residues is commonly observed in diverse environmental settings, where their interactions can potentially alter the behavior, availability, an...
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The transcription factor MdERF023 negatively regulates salt tolerance by modulating ABA signaling and Na+/H+ transport in apple
MdERF023 is a transcription factor that can reduce salt tolerance by inhibiting ABA signaling and Na+/H+ homeostasis.
