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Article
All-optically controlled memristor for dual-channel emotional circuit and its application
Most emotional neural network circuits only consider the generation of emotions, ignoring the effect of semantic linkage between different sensory channels on the intensity and rate of emotional generation. In...
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Article
Open AccessThe novel norcantharidin derivative DCZ5417 suppresses multiple myeloma progression by targeting the TRIP13–MAPK–YWHAE signaling pathway
Multiple myeloma (MM), an incurable disease owing to drug resistance, requires safe and effective therapies. Norcantharidin (NCTD), an active ingredient in traditional Chinese medicines, possesses activity aga...
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Article
Aberrant activation of TRIP13-EZH2 signaling axis promotes stemness and therapy resistance in multiple myeloma
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Article
Chicken swarm optimization with an enhanced exploration–exploitation tradeoff and its application
The chicken swarm optimization (CSO) is a novel swarm intelligence algorithm, which mimics the hierarchal order and foraging behavior in the chicken swarm. However, like other population-based algorithms, CSO ...
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Chapter and Conference Paper
Correlation Analysis of China's Renewable Energy and Carbon Emissions
CO2 emissions are of global concern because of climate change. China has become the largest CO2 emitter in the world and presently accounts for 30% of global emissions. This paper selects the energy consumption f...
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Article
Open AccessPreclinical validation and phase I trial of 4-hydroxysalicylanilide, targeting ribonucleotide reductase mediated dNTP synthesis in multiple myeloma
Aberrant DNA repair pathways contribute to malignant transformation or disease progression and the acquisition of drug resistance in multiple myeloma (MM); therefore, these pathways could be therapeutically ex...
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Chapter and Conference Paper
Chicken Swarm Optimization Algorithm Based on Hybrid Improvement Strategy
To solve the problem of high dimensional complex optimization, a global Hybrid Improved Chicken Swarm Optimization (HICSO) algorithm is proposed. Firstly, the initial population is constructed by a hybrid chao...
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Article
Open AccessA novel M phase blocker, DCZ3301 enhances the sensitivity of bortezomib in resistant multiple myeloma through DNA damage and mitotic catastrophe
DCZ3301, a novel aryl-guanidino compound previously reported by our group, exerts cytotoxic effects against multiple myeloma (MM), diffused large B cell lymphoma (DLBCL), and T-cell leukemia/lymphoma. However,...
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Article
Open AccessA novel silicone derivative of natural osalmid (DCZ0858) induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma via the JAK2/STAT3 pathway
Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous malignant tumor characterized by diffuse growth. DCZ0858 is a novel small molecule with excellent antitumor effects in DLBCL. This study explored...
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Chapter and Conference Paper
Predictive Values of Preoperative Index Analysis in Patients with Esophageal Squamous Cell Carcinoma
The prognostic nutritional index (PNI) has been widely used to predict survival outcomes of patients with various malignant tumors. The purpose of this study is to assess the prognostic value of PNI and analyz...
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Article
Open AccessFerroportin downregulation promotes cell proliferation by modulating the Nrf2–miR-17-5p axis in multiple myeloma
Recent findings demonstrate that aberrant downregulation of the iron-exporter protein, ferroportin (FPN1), is associated with poor prognosis and osteoclast differentiation in multiple myeloma (MM). Here, we sh...
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Article
Modeling and analysis of under-load-based cascading failures in supply chain networks
The phenomena of cascading failures often happen in complex networks. In most infrastructure networks, the subsequent failures of nodes are caused by overload and many overload cascading failure models are dev...
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Article
Open AccessDCZ3301, a novel cytotoxic agent, inhibits proliferation in diffuse large B-cell lymphoma via the STAT3 pathway
Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma in adults, characterized by a rapidly increasing painless mass. A novel compound, DCZ3301, was synthesized that exerted direct cytotoxi...
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Article
FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation
F-box and WD repeat domain-containing 7 (FBW7), the substrate-binding subunit of E3 ubiquitin ligase SCFFBW7 (a complex of SKP1, cullin-1 and FBW7), plays important roles in various physiological and pathological...
