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Article
Inhibition of USP10 induces myeloma cell apoptosis by promoting cyclin D3 degradation
The cell cycle regulator cyclin D3 (CCND3) is highly expressed in multiple myeloma (MM) and it promotes MM cell proliferation. After a certain phase of cell cycle, CCND3 is rapidly degraded, which is essential...
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Article
Open AccessPreimplantation genetic diagnosis and screening (PGD/S) using a semiconductor sequencing platform
Recent advances in semiconductor sequencing platform (SSP) have provided new methods for preimplantation genetic diagnosis/screening (PGD/S). The present study aimed to evaluate the applicability and efficienc...
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Article
Open AccessChromosomal abnormalities: subgroup analysis by maternal age and perinatal features in zhejiang province of China, 2011–2015
Recently, the prevalence of chromosomal abnormalities (CA) increased as the increasing proportion of mothers with advanced age. We aimed to explore the prevalence of CA in relation to maternal age and perinata...
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Article
Open AccessInvolvement of Cl−/HCO3− exchanger SLC26A3 and SLC26A6 in preimplantation embryo cleavage
Bicarbonate (HCO3−) is essential for preimplantation embryo development. However, the mechanism underlying the HCO3− transport into the embryo remains elusive. In the present study, we examined the possible invol...
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Chapter
Physiology of Gametogenesis
Gametogenesis is a biological process by which diploid or haploid precursor cells undergo cell division and differentiation to form mature haploid gametes. The biology of gamete production is different between...
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Article
Different sperm sources and parameters can influence intracytoplasmic sperm injection outcomes before embryo implantation
To evaluate the effects of sperm with different parameters and sources on the outcomes of intracytoplasmic sperm injection (ICSI), 1972 ICSI cycles were analyzed retrospectively. Groups 1 to 5 were composed of...
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Article
Accuracy of a combined score of zygote and embryo morphology for selecting the best embryos for IVF
To evaluate the accuracy of a scoring system combining zygote and embryo morphology in predicting the outcome of in vitro fertilization (IVF) treatment.
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Article
Identification of embryonic chromosomal abnormality using FISH-based preimplantaion genetic diagnosis
Objective: Embryonic chromosomal abnormality is one of the main reasons for in vitro fertilization (IVF) failure. This study aimed at evaluating the value of Fluorescence in-situ Hybridization (FISH)-based Pre...
