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Open AccessInhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice
Ginsenoside Rg3, a saponin extracted from ginseng, inhibits angiogenesis. The combination of low-dose chemotherapy and anti-angiogenic inhibitors suppresses growth of experimental tumors more effectively than ...
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Article
Open AccessGenetic variants in the MRPS30 region and postmenopausal breast cancer risk
Genome-wide association studies have identified several genomic regions that are associated with breast cancer risk, but these provide an explanation for only a small fraction of familial breast cancer aggrega...
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Evidence-based Materia Medica for Cancer Chemoprevention
Cancer is the second leading cause of death in the world, and current therapeutic outcomes are still not satisfactory. Cancer chemoprevention is an important strategy to reduce cancer morbidity by using non- o...
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Open AccessErratum To: Genetic variants in the MRPS30region and postmenopausal breast cancer risk
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Open AccessInhibitory effect of Bifidobacterium infantis-mediated sKDR prokaryotic expression system on angiogenesis and growth of Lewis lung cancer in mice
To construct the Bifidobacterium infantis-mediated soluble kinase insert domain receptor (sKDR) prokaryotic expression system and to observe its inhibitory effect on growth of human umbilicus vessel endothelial c...
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Open AccessExploring the interaction between SNP genotype and postmenopausal hormone therapy effects on stroke risk
Genome-wide association studies have identified several genomic regions that are associated with stroke risk, but these provide an explanation for only a small fraction of familial stroke aggregation. Genotype...
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Article
Open AccessEvaluation of transabdominal ultrasound after oral administration of an echoic cellulose-based gastric ultrasound contrast agent for gastric cancer
With the remarkable improvements in ultrasound equipment, transabdominal ultrasound after oral administration of an echoic cellulose-based gastric ultrasound contrast agent (TUS-OCCA) has recently been suggest...
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Open AccessDownregulated SPINK4 is associated with poor survival in colorectal cancer
SPINK4 is known as a gastrointestinal peptide in the gastrointestinal tract and is abundantly expressed in human goblet cells. The clinical significance of SPINK4 in colorectal cancer (CRC) is largely unknown.
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Open AccessTissue mechanics and expression of TROP2 in oral squamous cell carcinoma with varying differentiation
Trophoblast cell surface antigen 2 (TROP2) is overexpressed in many squamous cell carcinomas and promotes tumor development and invasion. The association between TROP2 expression and occurrence and development...
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Open AccessRisk stratification of lateral neck recurrence for patients with pN1a papillary thyroid cancer
Lateral neck is not recommended for dissection in patients with pN1a papillary thyroid cancer (PTC), but its recurrence risk has not been well stratified. We aimed to develop a risk stratification system for l...
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Open AccessiRGD-modified memory-like NK cells exhibit potent responses to hepatocellular carcinoma
Cytokine-induced memory-like natural killer (CIML NK) cells have been found to possess potent antitumor responses and induce complete remissions in patients with leukemia. However, the poor infiltration of tra...
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Open AccessThe oncogenic role of NF1 in gallbladder cancer through regulation of YAP1 stability by direct interaction with YAP1
Gallbladder cancer (GBC) is the most prevalent and invasive biliary tract malignancy. As a GTPase-activating protein, Neurofibromin 1 (NF1) is a tumor suppressor that negatively regulates the RAS signaling pat...
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Open AccessCorrection: iRGD-modified memory-like NK cells exhibit potent responses to hepatocellular carcinoma
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Open AccessNeutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis
Infectious pancreatic necrosis (IPN) is a serious complication of acute pancreatitis, and early recognition and timely intervention are the keys to improving clinical outcomes. The purpose of this study was to...
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Open AccessRedox proteomics of PANC-1 cells reveals the significance of HIF-1 signaling protein oxidation in pancreatic ductal adenocarcinoma pathogenesis
Protein cysteine oxidation is substantially involved in various biological and pathogenic processes, but its implications in pancreatic cancer development remains poorly understood.
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Open AccessSpatial distribution pattern of immune cells is associated with patient prognosis in colorectal cancer
The spatial context of tumor-infiltrating immune cells (TIICs) is important in predicting colorectal cancer (CRC) patients’ clinical outcomes. However, the prognostic value of the TIIC spatial distribution is ...