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Article
Curcumin inhibits the pruritus in mice through mast cell MrgprB2 receptor
Curcumin is a diketone compound extracted from the rhizomes of some plants in the Zingiberaceae and Araceae family. It possesses a variety of biological activities, including antioxidant, anti-inflammatory and...
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Article
Dhx33 promotes B-cell growth and proliferation by controlling activation-induced rRNA upregulation
Upon recognition of foreign antigens, naïve B cells undergo rapid activation, growth, and proliferation. How B-cell growth and proliferation are coupled with activation remains poorly understood. Combining CRI...
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Article
Open AccessCorrection: Simplified regimen of combined low-dose rituximab for autoimmune encephalitis with neuronal surface antibodies
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Article
Open AccessSimplified regimen of combined low-dose rituximab for autoimmune encephalitis with neuronal surface antibodies
Autoimmune encephalitis (AE) with neuronal surface antibodies (NSAbs) presents pathogenesis mediated by B cell-secreting antibodies. Rituximab is a second-line choice for the treatment for AE with NSAbs, which...
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Article
Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity
Neutrophils are derived from bone marrow hematopoietic stem cells (HSCs) and are the largest population among circulating white blood cells in humans, acting as the first line of defense against invading patho...
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Article
IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3
Intestinal stem cells (ISCs) are maintained by stemness signaling for precise modulation of self-renewal and differentiation under homeostasis. However, the way in which intestinal immune cells regulate the se...
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Article
The Regulatory Roles of Toll-Like Receptor 4 in Secretions of Type 1/Type 2 Relative Cytokines by Splenocytes and Dendritic Cells Exposed to Clonorchis sinensis Excretory/Secretory Products
The roles of TLR4 in mediation of innate immune response and in regulation of adaptive immune responses triggered by Clonorchis sinensis remain unknown. In the present study, splenocytes derived from C3H/HeN (TLR...
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Article
The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity
Cyclic diadenylate monophosphate (c-di-AMP) is secreted by bacteria as a secondary messenger. How immune cells detect c-di-AMP and initiate anti-bacterial immunity remains unknown. We found that the endoplasmi...
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Article
Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression
Long noncoding RNAs contribute to the cell-type-specific regulation of gene expression. Fan and colleagues identify a unique conserved lncRNA, lncKdm2b, that is transcribed divergently from the Kdm2b gene and is ...
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Article
Open AccessAberrant activation of hedgehog signaling promotes cell proliferation via the transcriptional activation of forkhead Box M1 in colorectal cancer cells
Recent evidence suggests that the aberrant activation of Hedgehog (Hh) signaling by Gli transcription factors is characteristic of a variety of aggressive human carcinomas, including colorectal cancer (CRC). F...
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Article
Erratum: Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity
Nat. Immunol.; 10.1038/ni.3356; corrected online 29 February 2016 In the version of this article initially published online, the title of the legend to Figure 1 (“Mice deficient in CCP5 or CCP5 are susceptible...
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Article
Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity
cGAS is an important sensor of cytosolic DNA, but the mechanisms that regulate it remain largely unknown. Fan and colleagues demonstrate that cGAS and its DNA-binding activities are negatively regulated by glu...
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Article
Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection
Fan and colleagues show that Sox2, already known to function as a transcription factor that controls lineage specification during embryogenesis, also has a role as a cytosolic and sequence-specific sensor of b...
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Article
Molecular genetic characterization of the distal NKC recombination hotspot and putative murine CMV resistance control locus
The NK gene complex (NKC) controls murine cytomegalovirus (MCMV) immunity through Cmv1-dependent natural killer (NK) cell responses. Ly49H expression correlates with Cmv1 phenotypes in different inbred strains, i...
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Article
Natural killer gene complex (Nkc) allelic variability in inbred mice: evidence for Nkc haplotypes
Allelic variability for mouse Chromosome 6 Nkc loci was assessed in 22 common laboratory strains of mice using selected natural killer gene complex (Nkc)-linked sequence tagged site markers. Most Nkc markers dis...
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Article
Ten polymorphic DNA loci, including five in the rat MHC (RT1) region, form a single linkage group on rat chromosome 20
