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  1. Article

    Open Access

    Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes

    Mutations in the Contactin-associated protein-like 2 (CNTNAP2) gene are associated with autism spectrum disorder (ASD), and ectodomain shedding of the CNTNAP2 protein plays a role in its function. However, key en...

    Qing Zhang, Mengen **ng, Zhengkai Bao, Lu Xu… in Signal Transduction and Targeted Therapy (2024)

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  2. Article

    Open Access

    Clusterin transduces Alzheimer-risk signals to amyloidogenesis

    ** Liu, Rongbo Che, Wen** Liang, Yun Zhang… in Signal Transduction and Targeted Therapy (2022)

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  3. Article

    Open Access

    BACE2 degradation is mediated by both the proteasome and lysosome pathways

    Alzheimer’s disease is the most common neurodegenerative disease in the elderly. Amyloid-β protein (Aβ) is the major component of neuritic plaques which are the hallmark of AD pathology. β-site APP cleaving en...

    Kaixin Qiu, Wen** Liang, Shuai Wang, Tingting Kong… in BMC Molecular and Cell Biology (2020)

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  4. No Access

    Article

    A Novel Alzheimer-Associated SNP in Tmp21 Increases Amyloidogenesis

    Recent studies suggest that TMP21 is a selective modulator of γ-secretase and its dysregulation affects APP processing, leading to increased Aβ generation. However, the genetic association between Tmp21 and Alzhe...

    **aojie Zhang, Yili Wu, Fang Cai, Shengchun Liu… in Molecular Neurobiology (2018)

  5. No Access

    Article

    A genome-wide association study of cognitive function in Chinese adult twins

    Multiple loci or genes have been identified using genome-wide association studies mainly in western countries but with inconsistent results. No similar studies have been conducted in the world’s largest and ra...

    Chunsheng Xu, Dongfeng Zhang, Yili Wu, **aocao Tian, Zengchang Pang… in Biogerontology (2017)

  6. No Access

    Article

    Upregulation of SET Expression by BACE1 and its Implications in Down Syndrome

    Down syndrome (DS) is one of the most common genetic diseases. Patients with DS display growth delay and intellectual disabilities and develop Alzheimer’s disease (AD) neuropathology after middle age, includin...

    **aozhu Zhang, Yili Wu, **aoling Duan, Wei Chen, Haiyan Zou… in Molecular Neurobiology (2015)

  7. No Access

    Article

    Aberrant Expression of RCAN1 in Alzheimer’s Pathogenesis: A New Molecular Mechanism and a Novel Drug Target

    AD, a devastating neurodegenerative disorder, is the most common cause of dementia in the elderly. Patients with AD are characterized by three hallmarks of neuropathology including neuritic plaque deposition, ...

    Yili Wu, Philip T. T. Ly, Weihong Song in Molecular Neurobiology (2014)