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Article
Open AccessWhole-exome sequencing detected a novel AIFM1 variant in a Han-Chinese family with Cowchock syndrome
Charcot-Marie-Tooth disease(CMT) is a hereditary peripheral neuropathy, characterized by progressive distal hypoesthesia and amyotrophia. CMT is characterized by an X- linked recessive inheritance pattern. The...
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Article
Open AccessPioLaG: a piosphere landscape generator for savanna rangeland modelling
Piospheres describe herbivore utilization gradients around watering points, as commonly found in grass-dominated ecosystems. Spatially explicit, dynamic models are ideal tools to study the ecological and econo...
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Article
Open AccessGenome-wide DNA methylation changes in skeletal muscle between young and middle-aged pigs
Age-related physiological, biochemical and functional changes in mammalian skeletal muscle have been shown to begin at the mid-point of the lifespan. However, the underlying changes in DNA methylation that occ...
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Article
Open AccessIndividual aortic baroreceptors are sensitive to different ranges of blood pressures
Many receptors, including thermal receptors and mechanical receptors, are only activated by stimuli within a clearly defined range of intensities. Differences in the receptive ranges enable individual receptor...
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Article
Induction of GM1a/GD1b synthase triggers complex ganglioside expression and alters neuroblastoma cell behavior; a new tumor cell model of ganglioside function
Neuroblastoma is the most common extracranial solid tumor in children and tumor ganglioside composition has been linked to its biological and clinical behavior. We recently found that high expression of comple...