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Article
Open AccessIFI35 limits antitumor immunity in triple-negative breast cancer via CCL2 secretion
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer with poor prognosis due to the lack of therapeutic targets. Although immunotherapy brings survival benefits to patients diag...
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Article
Open AccessA self-healing electrocatalytic system via electrohydrodynamics induced evolution in liquid metal
Catalytic deterioration during electrocatalytic processes is inevitable for conventional composite electrodes, which are prepared by depositing catalysts onto a rigid current collector. In contrast, metals tha...
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Article
NSrp70 suppresses metastasis in triple-negative breast cancer by modulating Numb/TβR1/EMT axis
Alternative splicing of mRNA precursors allows cancer cells to create different protein isoforms that promote growth and survival. Compared to normal cells, cancer cells frequently exhibit a higher diversity o...
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Article
Open AccessEpigenetic regulation of thermomorphogenesis in Arabidopsis thaliana
Temperature is a key factor in determining plant growth and development, geographical distribution, and seasonal behavior. Plants accurately sense subtle changes in ambient temperature and alter their growth a...
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Article
Open AccessDGKZ promotes TGFβ signaling pathway and metastasis in triple-negative breast cancer by suppressing lipid raft-dependent endocytosis of TGFβR2
Diacylglycerol kinase ζ (DGKZ) is a diacylglycerol kinase that metabolizes diacylglycerol to yield phosphatidic acid, and its function in breast cancer progression remains unclear. In this study, via screening...
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Article
Open AccessConjoint analysis of circulating tumor cells and solid tumors for exploring potential prognostic markers and constructing a robust novel predictive signature for breast cancer
Distance metastasis is the leading cause of death for breast cancer patients, and circulating tumor cells (CTCs) play a key role in cancer metastasis. There have been few studies on CTCs at the molecular level...
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Article
NSDHL promotes triple-negative breast cancer metastasis through the TGFβ signaling pathway and cholesterol biosynthesis
Metastasis is the main cause of breast cancer mortality. Recent studies have proved that lipid metabolic reprogramming plays critical roles in breast cancer carcinogenesis and metastasis. We aim to identify cr...
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Article
Open AccessSentinel node theory helps tracking of primary lesions of cancers of unknown primary
Sentinel lymph node is the first stop of lymphatic spreading of cancer with known primary. The lymph node metastasis pattern of cancer of unknown primary (CUP) is unclear and has been presumed to follow the sa...
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Article
About the Modeling of the Indentation of a Virus Shell: The Role of the Shape of the Probe
This article studies the effect of the geometry of the probe on the nanoindentation of a virus. Theoretical continuum models and numerical simulations are presented for two different probes with different shap...
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Article
Open AccessIntegrative genome-wide analysis reveals HLP1, a novel RNA-binding protein, regulates plant flowering by targeting alternative polyadenylation
Alternative polyadenylation (APA) is a widespread mechanism for gene regulation and has been implicated in flowering, but the molecular basis governing the choice of a specific poly(A) site during the vegetati...
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Article
Role of Intracellular Calcium in Proteasome Inhibitor-Induced Endoplasmic Reticulum Stress, Autophagy, and Cell Death
Proteasome inhibition induces endoplasmic reticulum (ER) stress and compensatory autophagy to relieve ER stress. Disturbance of intracellular calcium homeostasis can lead to ER stress and alter the autophagy p...
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Autophagy and Cancer Drug Discovery
Autophagy is a highly conserved lysosomal degradation pathway that is important for maintaining cellular homeostasis by degrading bulk cytoplasm and superfluous or damaged organelles. Autophagy plays a dual ro...
