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Open AccessResponse to: “Merit of integrating in situ transcriptomics and anatomical information for cell annotation and lineage construction in single-cell analyses of Populus”
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Open AccessThe Quartet Data Portal: integration of community-wide resources for multiomics quality control
The Quartet Data Portal facilitates community access to well-characterized reference materials, reference datasets, and related resources established based on a family of four individuals with identical twins ...
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Open AccessCorrecting batch effects in large-scale multiomics studies using a reference-material-based ratio method
Batch effects are notoriously common technical variations in multiomics data and may result in misleading outcomes if uncorrected or over-corrected. A plethora of batch-effect correction algorithms are propose...
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Open AccessMap** genetic variants for nonsense-mediated mRNA decay regulation across human tissues
Nonsense-mediated mRNA decay (NMD) was originally conceived as an mRNA surveillance mechanism to prevent the production of potentially deleterious truncated proteins. Research also shows NMD is an important po...
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Open AccessRAD21 is the core subunit of the cohesin complex involved in directing genome organization
The ring-shaped cohesin complex is an important factor for the formation of chromatin loops and topologically associating domains (TADs) by loop extrusion. However, the regulation of association between cohesi...
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Open AccessLarge-scale analysis of de novo mutations identifies risk genes for female infertility characterized by oocyte and early embryo defects
Oocyte maturation arrest and early embryonic arrest are important reproductive phenotypes resulting in female infertility and cause the recurrent failure of assisted reproductive technology (ART). However, the...
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Open AccessBIND&MODIFY: a long-range method for single-molecule map** of chromatin modifications in eukaryotes
Epigenetic modifications of histones are associated with development and pathogenesis of disease. Existing approaches cannot provide insights into long-range interactions and represent the average chromatin st...
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Open AccessThe histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots
The PRDM9-dependent histone methylation H3K4me3 and H3K36me3 function in assuring accurate homologous recombination at recombination hotspots in mammals. Beyond histone methylation, H3 lysine 9 acetylation (H3...
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Open AccessPtoNF-YC9-SRMT-PtoRD26 module regulates the high saline tolerance of a triploid poplar
Sensing and responding to stresses determine the tolerance of plants to adverse environments. The triploid Chinese white poplar is widely cultivated in North China because of its adaptation to a wide range of ...
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Open AccessDecoding the multicellular ecosystem of vena caval tumor thrombus in clear cell renal cell carcinoma by single-cell RNA sequencing
Vascular invasion with tumor thrombus frequently occurs in advanced renal cell carcinoma (RCC). Thrombectomy is one of the most challenging surgeries with high rate of perioperative morbidity and mortality. Ho...
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Dysregulated lncRNA and mRNA may promote the progression of ischemic stroke via immune and inflammatory pathways: results from RNA sequencing and bioinformatics analysis
Long non-coding RNAs (lncRNAs) are widely involved in gene transcription regulation and which act as epigenetic modifiers in many diseases.
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Open AccessYTHDF1 promotes the proliferation, migration, and invasion of prostate cancer cells by regulating TRIM44
Prostate cancer (PCa) is one of the most common malignancies in men. YTHDF1 may play an important role in promoting PCa progression, but there is no reports to date on YTHDF1 function in PCa.
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Open AccessTranscriptional landscape of highly lignified poplar stems at single-cell resolution
Plant secondary growth depends on the activity of the vascular cambium, which produces xylem and phloem. Wood derived from xylem is the most abundant form of biomass globally and has played key socio-economic ...
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Open AccessQuantifying the phase separation property of chromatin-associated proteins under physiological conditions using an anti-1,6-hexanediol index
Liquid-liquid phase separation (LLPS) is an important organizing principle for biomolecular condensation and chromosome compartmentalization. However, while many proteins have been reported to undergo LLPS, qu...
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Open AccessPublisher Correction: Leveraging breeding programs and genomic data in Norway spruce (Picea abies L. Karst) for GWAS analysis
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Open AccessLeveraging breeding programs and genomic data in Norway spruce (Picea abies L. Karst) for GWAS analysis
Genome-wide association studies (GWAS) identify loci underlying the variation of complex traits. One of the main limitations of GWAS is the availability of reliable phenotypic data, particularly for long-lived...
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Correction to: Profiling transcriptomic changes and signaling pathways in atopic dermatitis 2 by integrative analyses on multiple databases
A correction to this paper has been published: https://doi.org/10.1007/s00438-021-01770-5
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Open AccessMethylationToActivity: a deep-learning framework that reveals promoter activity landscapes from DNA methylomes in individual tumors
Although genome-wide DNA methylomes have demonstrated their clinical value as reliable biomarkers for tumor detection, subty**, and classification, their direct biological impacts at the individual gene leve...
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Open AccessPublisher Correction: Bayesian model selection reveals biological origins of zero inflation in single-cell transcriptomics
An amendment to this paper has been published and can be accessed via the original article.
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Open AccesssgBE: a structure-guided design of sgRNA architecture specifies base editing window and enables simultaneous conversion of cytosine and adenosine
We present a base editing system, in which base editors are attached to different sites of sgRNA scaffold (sgBE). Each independent sgBE has its own specific editing pattern for a given target site. Among teste...