78 Result(s)

Article

Epidemiology, economic, and humanistic burden of hereditary angioedema: a systematic review

This systematic study aims to assess the global epidemiologic, economic, and humanistic burden of illness associated with all types of hereditary angioedema.

**n Guan, Yanan Sheng, Shuang Liu, Miao He… in Orphanet Journal of Rare Diseases (2024)

Article

High-intensity Focused Ultrasound-A New Choice to Conduct Pulmonary Artery Denervation

This research aimed to explore whether high-intensity focused ultrasound (HIFU) could conduct pulmonary artery denervation (PADN). HIFU was performed in pulmonary arteries of 6 normotensive rabbits at dose of ...

Yonghui **e, Taoyue Yao, **aogang Zhu… in Journal of Cardiovascular Translational Re… (2024)

Article

Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation

The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance of intra-tumoral bacteria, such us E.coli, residing and resulting in Colorectal cancer liver me...

Jian Gu, **aozhang Xu, **angyu Li, Lei Yue, **aowen Zhu, Qiuyang Chen, Ji Gao… in Oncogene (2024)

Article

Correction: Targeting STAT3 by a small molecule suppresses pancreatic cancer progression

Huang Chen, Aiwu Bian, Lian-fang Yang, Xuan Yin, Jie Wang, Chaowen Ti… in Oncogene (2024)

Article

Exploring ALK fusion in colorectal cancer: a case series and comprehensive analysis

Anaplastic lymphoma kinase (ALK) fusion-positive colorectal cancer (CRC) is a rare and chemotherapy-refractory subtype that lacks established and effective treatment strategies. Additionally, the efficacy and ...

Zi-**g Li, William Pat Fong, Dong-Sheng Zhang, Hui-Yan Luo… in npj Precision Oncology (2024)

Article

Mild Therapeutic Hypothermia Alleviated Myocardial Ischemia/Reperfusion Injury via Targeting SLC25A10 to Suppress Mitochondrial Apoptosis

Myocardial ischemia/reperfusion injury (MI/RI) is identified as a severe vascular emergency, and the treatment strategy of MI/RI still needs further improvement. The present study aimed to investigate the pote...

Senlin Ma, Yun Song, Yanxin Xu, Chao Wang… in Journal of Cardiovascular Translational Re… (2024)

Article

Deep learning on tertiary lymphoid structures in hematoxylin-eosin predicts cancer prognosis and immunotherapy response

Tertiary lymphoid structures (TLSs) have been associated with favorable immunotherapy responses and prognosis in various cancers. Despite their significance, their quantification using multiplex immunohistoche...

Ziqiang Chen, **aobing Wang, Zelin **, Bosen Li, Dongxian Jiang… in npj Precision Oncology (2024)

Article

Tertiary lymphoid structures predict survival and response to neoadjuvant therapy in locally advanced rectal cancer

Tertiary lymphoid structure (TLS) contributes to the anti-tumor immune response, and predicts the prognosis of colorectal cancer patients. However, the potential impact of TLS in sha** the immune status of r...

Qianyu Wang, Wentao Zhong, **aofei Shen, Zechen Hao, Meng Wan… in npj Precision Oncology (2024)

Article

Immune microenvironment heterogeneity of concurrent adenocarcinoma and squamous cell carcinoma in multiple primary lung cancers

The molecular profiles and tumor immune microenvironment (TIME) of multiple primary lung cancers (MPLCs) presenting as concurrent lung adenocarcinoma (ADC) and squamous cell carcinoma (SQCC) remain unknown. We...

Jiahao Zhang, Yiheng Huang, Yichao Han, Dong Dong, Yuqin Cao… in npj Precision Oncology (2024)

Article

Multimodal fusion of liquid biopsy and CT enhances differential diagnosis of early-stage lung adenocarcinoma

This research explores the potential of multimodal fusion for the differential diagnosis of early-stage lung adenocarcinoma (LUAD) (tumor sizes < 2 cm). It combines liquid biopsy biomarkers, specifically extra...

Yanwei Zhang, Beibei Sun, Yinghong Yu, Jun Lu, Yuqing Lou… in npj Precision Oncology (2024)

Article

Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance

Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular heterogeneity and the immunosuppressive nature of the tumor microenvironment (TME). Tumor-associated macrophages (TAMs...

Shu**g Wang, **grui Wang, Zhiqiang Chen, Jiamin Luo, Wei Guo… in npj Precision Oncology (2024)

Article

SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair

Endometrial cancer (EC) stands as one of the most prevalent malignancies affecting the female genital tract, witnessing a rapid surge in incidence globally. Despite the well-established association of histone ...

Yujia Huang, Ming Tang, Zhiyi Hu, Bailian Cai, Guofang Chen, Lijun Jiang… in Oncogenesis (2024)

Article

Comprehensive assessment of the genetic characteristics of small for gestational age newborns in NICU: from diagnosis of genetic disorders to prediction of prognosis

In China, ~1,072,100 small for gestational age (SGA) births occur annually. These SGA newborns are a high-risk population of developmental delay. Our study aimed to evaluate the genetic profile of SGA newborns...

Hui **ao, Huiyao Chen, **ang Chen, Yulan Lu, Bingbing Wu, Huijun Wang… in Genome Medicine (2023)

Article

Kinesin family member 18B activates mTORC1 signaling via actin gamma 1 to promote the recurrence of human hepatocellular carcinoma

The mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway is frequently reported to be hyperactivated in hepatocellular carcinoma (HCC) and contributes to HCC recurrence. However, the underlying...

Qian Li, Mengqing Sun, Yao Meng, Mengqing Feng, Menglan Wang, Cunjie Chang… in Oncogenesis (2023)

Article

MC1R signaling through the cAMP-CREB/ATF-1 and ERK-NFκB pathways accelerates G1/S transition promoting breast cancer progression

MC1R, a G-protein coupled receptor, triggers ultraviolet light-induced melanin synthesis and DNA repair in melanocytes and is implicated in the pathogenesis of melanoma. Although widely expressed in different ...

Vipin Shankar Chelakkot, Kiara Thomas, Todd Romigh, Andrew Fong… in npj Precision Oncology (2023)

Article

FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation

FBXO28 is a member of F-box proteins that are the substrate receptors of SCF (SKP1, CULLIN1, F-box protein) ubiquitin ligase complexes. Despite the implications of its role in cancer, the function of FBXO28 in...

**nran Qiao, **gyu Lin, Jiajia Shen, Yang Chen, Liyun Zheng, Hangjiang Ren… in Oncogene (2023)

Article

Exploring the methylation status of CFTR and PKIA genes as potential biomarkers for lung adenocarcinoma

One of the most prevalent cancers in the world is lung cancer, with adenocarcinoma (LUAD) making up a significant portion of cases. According to the National Cancer Institute (NCI), there are new cases and fat...

Bowen Xu, **gang Zhang, Weigang Chen, Wei Cai in Orphanet Journal of Rare Diseases (2023)

Article

Retraction Note: Hsp90β promotes aggressive vasculogenic mimicry via epithelial–mesenchymal transition in hepatocellular carcinoma

**g Meng, Shuang Chen, Yue-yang Lei, **g-xia Han, Wei-long Zhong… in Oncogene (2023)

Article

Antibody-based binding domain fused to TCRγ chain facilitates T cell cytotoxicity for potent anti-tumor response

Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated potent clinical efficacy in the treatment of hematopoietic malignancies. However, the application of CAR-T in solid tumors has been limited due...

Zhao Chen, Changyou Lin, Hong Pei, **aomei Yuan, Jia Xu, Mingwei Zou… in Oncogenesis (2023)

Article

Retraction Note: LINC01410-miR-532-NCF2-NF-kB feedback loop promotes gastric cancer angiogenesis and metastasis

Jia-**ng Zhang, Zhen-Hua Chen, Dong-Liang Chen, **ao-Peng Tian, Chen-Yuan Wang… in Oncogene (2023)