67 Result(s)

Article

Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation

The role of tumor-resident microbiota in modulating tumor immunity remains unclear. Here, we discovered an abundance of intra-tumoral bacteria, such us E.coli, residing and resulting in Colorectal cancer liver me...

Jian Gu, **aozhang Xu, **angyu Li, Lei Yue, **aowen Zhu, Qiuyang Chen, Ji Gao… in Oncogene (2024)

Article

Correction: Targeting STAT3 by a small molecule suppresses pancreatic cancer progression

Huang Chen, Aiwu Bian, Lian-fang Yang, Xuan Yin, Jie Wang, Chaowen Ti… in Oncogene (2024)

Article

NT-3 Combined with TGF-β Signaling Pathway Enhance the Repair of Spinal Cord Injury by Inhibiting Glial Scar Formation and Promoting Axonal Regeneration

This study investigated the mechanism of neurotrophin-3 (NT-3) in promoting spinal cord injury repair through the transforming growth factor-beta (TGF-β) signaling pathway. A mouse model of spinal cord injury ...

Taibang Chen, **aoqing He, **g Wang, Di Du, Yongqing Xu in Molecular Biotechnology (2024)

Article

SMYD3 promotes endometrial cancer through epigenetic regulation of LIG4/XRCC4/XLF complex in non-homologous end joining repair

Endometrial cancer (EC) stands as one of the most prevalent malignancies affecting the female genital tract, witnessing a rapid surge in incidence globally. Despite the well-established association of histone ...

Yujia Huang, Ming Tang, Zhiyi Hu, Bailian Cai, Guofang Chen, Lijun Jiang… in Oncogenesis (2024)

Article

Kinesin family member 18B activates mTORC1 signaling via actin gamma 1 to promote the recurrence of human hepatocellular carcinoma

The mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway is frequently reported to be hyperactivated in hepatocellular carcinoma (HCC) and contributes to HCC recurrence. However, the underlying...

Qian Li, Mengqing Sun, Yao Meng, Mengqing Feng, Menglan Wang, Cunjie Chang… in Oncogenesis (2023)

Article

Estimating genome-wide DNA methylation heterogeneity with methylation patterns

In a heterogeneous population of cells, individual cells can behave differently and respond variably to the environment. This cellular diversity can be assessed by measuring DNA methylation patterns. The loci ...

Pei-Yu Lin, Ya-Ting Chang, Yu-Chun Huang, Pao-Yang Chen in Epigenetics & Chromatin (2023)

Article

FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation

FBXO28 is a member of F-box proteins that are the substrate receptors of SCF (SKP1, CULLIN1, F-box protein) ubiquitin ligase complexes. Despite the implications of its role in cancer, the function of FBXO28 in...

**nran Qiao, **gyu Lin, Jiajia Shen, Yang Chen, Liyun Zheng, Hangjiang Ren… in Oncogene (2023)

Article

Retraction Note: Hsp90β promotes aggressive vasculogenic mimicry via epithelial–mesenchymal transition in hepatocellular carcinoma

**g Meng, Shuang Chen, Yue-yang Lei, **g-xia Han, Wei-long Zhong… in Oncogene (2023)

Article

Antibody-based binding domain fused to TCRγ chain facilitates T cell cytotoxicity for potent anti-tumor response

Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated potent clinical efficacy in the treatment of hematopoietic malignancies. However, the application of CAR-T in solid tumors has been limited due...

Zhao Chen, Changyou Lin, Hong Pei, **aomei Yuan, Jia Xu, Mingwei Zou… in Oncogenesis (2023)

Article

Phase I study of A166, an antibody‒drug conjugate in advanced HER2-expressing solid tumours

In this phase I study, the safety, pharmacokinetics, and antitumour activity of the HER2-targeted antibody–drug conjugate A166 were evaluated in patients with HER2-expressing advanced solid tumours. Patients w...

Jian Zhang, Rujiao Liu, Shui** Gao, Wenhua Li, Yang Chen… in npj Breast Cancer (2023)

Article

Retraction Note: LINC01410-miR-532-NCF2-NF-kB feedback loop promotes gastric cancer angiogenesis and metastasis

Jia-**ng Zhang, Zhen-Hua Chen, Dong-Liang Chen, **ao-Peng Tian, Chen-Yuan Wang… in Oncogene (2023)

Article

Characterization of the Immune Infiltration Landscape and Identification of Prognostic Biomarkers for Esophageal Cancer

Immunotherapy is an effective treatment for esophageal cancer (ESCA) patients. However, there are no dependable markers for predicting prognosis and immunotherapy responses in ESCA. Our study aims to explore i...

Yuanmei Chen, **nyi Huang, Lin Chen, Guibin Weng… in Molecular Biotechnology (2023)

Article

The hTERT-p50 homodimer inhibits PLEKHA7 expression to promote gastric cancer invasion and metastasis

Although accumulating evidence has highlighted the molecular mechanisms by which hTERT promotes tumour cell invasion and metastasis, the molecular mechanisms of the properties enabling hTERT to contribute to i...

Yu-Yun Wu, Yu-Feng **ao, Li-**ng Tian, Bing He, Jiao Liu, Zhi-Bin Li, Huan Yang… in Oncogene (2023)

Article

Diltiazem inhibits breast cancer metastasis via mediating growth differentiation factor 15 and epithelial-mesenchymal transition

Migration and metastasis commonly happen to triple-negative breast cancer (TNBC) patients with advanced diseases. In many studies, it has been suggested that epithelial-mesenchymal transition (EMT) is one of t...

Yen-Chang Chen, Chen-Teng Wu, Jia-Hong Chen, Cheng-Fang Tsai, Chen-Yun Wu… in Oncogenesis (2022)

Article

LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells

LIN28 is an RNA binding protein with important roles in early embryo development, stem cell differentiation/reprogramming, tumorigenesis and metabolism. Previous studies have focused mainly on its role in the ...

Zhen Sun, Hua Yu, **g Zhao, Tianyu Tan, Hongru Pan, Yuqing Zhu… in Protein & Cell (2022)

Article

TCRP1 activated by mutant p53 promotes NSCLC proliferation via inhibiting FOXO3a

Previously, our lab explored that tongue cancer resistance-associated protein (TCRP1) plays a central role in cancer chemo-resistance and progression. Absolutely, TCRP1 was significantly increased in lung canc...

Hao Liu, **aoting Jia, Kai Luo, **angzhou Chen, Zhijie Zhang, Danyang Chen… in Oncogenesis (2022)

Article

Correction to: EphA2–YES1–ANXA2 pathway promotes gastric cancer progression and metastasis

Linfeng Mao, Weijie Yuan, Kaimei Cai, Chen Lai, Changhao Huang, Yi Xu… in Oncogene (2022)

Article

Autophagy regulates the cancer stem cell phenotype of head and neck squamous cell carcinoma through the noncanonical FOXO3/SOX2 axis

Autophagy is an essential catabolic process that orchestrates cellular homeostasis and plays dual roles in tumor promotion and suppression. However, the mechanism by which autophagy affects the self-renewal of...

Yang Chen, Hui Zhao, Weilian Liang, Erhui Jiang, **aocheng Zhou, Zhe Shao… in Oncogene (2022)

Article

Correction: AR-induced long non-coding RNA LINC01503 facilitates proliferation and metastasis via the SFPQ-FOSL1 axis in nasopharyngeal carcinoma

Shi-Wei He, Cheng Xu, Ying-Qing Li, Ying-Qin Li, Yin Zhao, Pan-Pan Zhang… in Oncogene (2021)

Article

Higher-order assemblies in immune signaling: supramolecular complexes and phase separation

Signaling pathways in innate and adaptive immunity play vital roles in pathogen recognition and the functions of immune cells. Higher-order assemblies have recently emerged as a central principle that governs ...

Shiyu **a, Zhenhang Chen, Chen Shen, Tian-Min Fu in Protein & Cell (2021)