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  1. Article

    Open Access

    NT-3 Combined with TGF-β Signaling Pathway Enhance the Repair of Spinal Cord Injury by Inhibiting Glial Scar Formation and Promoting Axonal Regeneration

    This study investigated the mechanism of neurotrophin-3 (NT-3) in promoting spinal cord injury repair through the transforming growth factor-beta (TGF-β) signaling pathway. A mouse model of spinal cord injury ...

    Taibang Chen, **aoqing He, **g Wang, Di Du, Yongqing Xu in Molecular Biotechnology (2024)

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  2. No Access

    Article

    Circ_0000115 Protects Against Cerebral Ischemia Injury by Suppressing Neuronal Apoptosis, Oxidative Stress and Inflammation by miR-1224-5p/Nos3 Axis In Vitro

    Cerebral ischemia is a severe neurological disability related to neuronal apoptosis and cellular stress response. Circular RNAs (circRNAs) are emerging regulators of cerebral ischemia. Herein, this study propo...

    Ying Cao, Yanbing Xu, Rui Zhang, Junsheng Qi, Qiuyu Su… in Molecular Biotechnology (2024)

  3. No Access

    Article

    Investigation of Circular RNA Expression Profiles in Ultrasound-guided Incomplete Radiofrequency Ablation Transplanted Tumor Models of Human Liver Cancer

    Abnormally expressed circular RNAs (circRNAs) are associated with many diseases and have important biological effects on the regulation of gene expression. However, the circRNA expression profile in incomplete...

    Dongyue Wen, Jiamin Chen, Peng Lin, **shu Pang, Yuyan Pang… in Molecular Biotechnology (2024)

  4. No Access

    Article

    Circular RNA PIP5K1A Promotes Glucose and Lipid Metabolism Disorders and Inflammation in Type 2 Diabetes Mellitus

    Disorders of glucose and lipid metabolism are an important cause of type 2 diabetes mellitus (T2DM). Identifying the molecular mechanism of metabolic disorders is key to the treatment of T2DM. The study was to...

    Ge Song, YiQian Zhang, YiHua Jiang, Huan Zhang, Wen Gu, **u Xu… in Molecular Biotechnology (2023)

  5. No Access

    Article

    ITGB4 Serves as an Identification and Prognosis Marker Associated with Immune Infiltration in Small Cell Lung Carcinoma

    Integrin beta 4 (ITGB4) is a vital factor for numerous cancers. However, no reports regarding ITGB4 in small cell lung carcinoma (SCLC) have been found in the existing literature. This study systematically invest...

    Guo-Sheng Li, Zhi-Guang Huang, Rong-Quan He, Wei Zhang… in Molecular Biotechnology (2023)

  6. No Access

    Article

    CYTOR Promotes Proliferation of Lung Cancer Cell by Targeting miR-103a-3p to Upregulate HMGB1

    Lung cancer is one of the most dangerous malignant tumors to human health in the world. Previous researches have shown that cytoskeleton regulator RNA (CYTOR), a long noncoding RNA was involved in the occurren...

    **nxin Xu, Yi Chen, Yan Zhang, Hua Cai, Pei Shen, **g**g Peng… in Molecular Biotechnology (2023)

  7. Article

    Open Access

    Characterization of the Immune Infiltration Landscape and Identification of Prognostic Biomarkers for Esophageal Cancer

    Immunotherapy is an effective treatment for esophageal cancer (ESCA) patients. However, there are no dependable markers for predicting prognosis and immunotherapy responses in ESCA. Our study aims to explore i...

    Yuanmei Chen, **nyi Huang, Lin Chen, Guibin Weng… in Molecular Biotechnology (2023)

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  8. No Access

    Article

    LncRNA XIST Prevents Tendon Adhesion and Promotes Tendon Repair Through the miR-26a-5p/COX2 Pathway

    Tendon adhesion is the biggest obstacle to repair of tendon injury. Long-chain non-coding RNA X-inactive specific transcript (lncRNA XIST) is highly expressed in populations at high risk of tendon injury. Howe...

    Qiang Chen, Dongjie Hou, Yan Suo, Ziguan Zhu in Molecular Biotechnology (2022)

  9. No Access

    Article

    Development and Application of a Real-time PCR Method for Pharmacokinetic and Biodistribution Studies of Recombinant Adenovirus

    A replication-deficient recombinant adenovirus (Ad5-LFA-3/IgG1) that encodes secreted LFA-3/IgG1 was constructed for gene therapy treatment of psoriasis. The purpose of this study was to develop a real-time PCR m...

    **an-**ng Xu, Xue Shui, Zhi-Hang Chen, Cheng-Qi Shan, Yu-Nan Hou… in Molecular Biotechnology (2009)

  10. No Access

    Article

    Cloning a Truncated Fragment (stx2a1) of the Shiga-Like Toxin 2A1 Subunit of EHEC O157:H7: Candidate Immunogen for a Subunit Vaccine

    Shiga toxins consist of enzymatically active A and B subunit multimers. The A subunit of shiga-like toxins can be proteolytically cleaved into two parts, A1 and A2, with A1 being responsible for toxic activity. A...

    Lu Liu, Hao Zeng, ** Luo, Jian Wu, Hongzhang Chen, Yun Shi… in Molecular Biotechnology (2009)

  11. No Access

    Article

    A Novel Technique for Efficient Construction of Large scFv Libraries

    The development of patient-tailored anti-tumor therapies requires large-scale production of antibodies for the purpose of screening specific tumor antibodies. Thus, the generation of a single chain fragment of...

    Weijun Qin, Aizhi Zhao, Yueheng Han, Weihong Wen, Yu Li… in Molecular Biotechnology (2007)

  12. No Access

    Article

    Agrobacterium-mediated transformation of élite indica and japonica rice cultivars

    A rapid, efficient, routine system has been established forAgrobacterium tumefaciens-mediated production of hundreds of fertile transgenic plants from commercially important rice cultivars, including an indica cu...

    Jian Zhang, Rui-ji Xu, Malcolm C. Elliott, Dong-Fang Chen in Molecular Biotechnology (1997)