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Open AccessSingle test-based diagnosis of multiple cancer types using Exosome-SERS-AI for early stage cancers
Early cancer detection has significant clinical value, but there remains no single method that can comprehensively identify multiple types of early-stage cancer. Here, we report the diagnostic accuracy of simu...
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Article
Erratum: Dosimetric calibration of nanodot optically stimulated luminescent dosimeter for intraoperative radiotherapy with low-energy X-rays
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Dosimetric calibration of nanodot optically stimulated luminescent dosimeter for intraoperative radiotherapy with low-energy X-rays
The purpose of this study was to evaluate the dosimetric characteristics of optically stimulated luminescent dosimeters (OSLDs) for application in intraoperative radiotherapy (IORT). Dose measurements were per...
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Article
Open AccessCompact bunker shielding assessment for 1.5 T MR-Linac
This study evaluated the effect of the 1.5 T magnetic field of the magnetic resonance-guided linear accelerator (MR-Linac) on the radiation leakage doses penetrating the bunker radiation shielding wall. The ev...
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Article
Open AccessTumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution
Metastatic spread of a cancer to secondary sites is a coordinated, non-random process. Cancer cell-secreted vesicles, especially exosomes, have recently been implicated in the guidance of metastatic disseminat...
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Article
Open AccessLow-dose CBCT reconstruction via joint non-local total variation denoising and cubic B-spline interpolation
This study develops an improved Feldkamp–Davis–Kress (FDK) reconstruction algorithm using non-local total variation (NLTV) denoising and a cubic B-spline interpolation-based backprojector to enhance the image ...
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Article
Open AccessDual size-exclusion chromatography for efficient isolation of extracellular vesicles from bone marrow derived human plasma
Isolation of pure extracellular vesicles (EVs), especially from blood, has been a major challenge in the field of EV research. The presence of lipoproteins and soluble proteins often hinders the isolation of h...
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Levels of Extracellular Vesicles in Pulmonary and Peripheral Blood Correlate with Stages of Lung Cancer Patients
The extracellular vesicle (EV) concentration is known to be higher in cancer patients than in healthy individuals. Herein, we report that EV levels differ in the tumor-draining pulmonary vein blood and the per...
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Article
Open AccessQuantum biological tunnel junction for electron transfer imaging in live cells
Quantum biological electron transfer (ET) essentially involves in virtually all important biological processes such as photosynthesis, cellular respiration, DNA repair, cellular homeostasis, and cell death. Ho...
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Self-targeted knockdown of CD44 improves cisplatin sensitivity of chemoresistant non-small cell lung cancer cells
Chemoresistance remains a major challenge for effective chemotherapy of non-small-cell lung carcinoma (NSCLC). CD44 expression is related to the susceptibility of various cancer cell types to anticancer drugs....
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Femtoliter scale quantitative injection control by experimental and theoretical modeling
Injection is a useful technology for delivery the solution like drug in medical science, because injection amount can be simply controlled by adjusting the injection duration and pressure. With advances in fab...
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Exosome identification for personalized diagnosis and therapy
Exosomes which are nano-sized vesicles secreted from cell to extracellular fluid have received an emerging interest because it has been believed that they have specialized function such as stimulating immune s...
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Special issue on nano/biotechnology
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Nanowire-based single-cell endoscopy
One-dimensional smart probes based on nanowires and nanotubes that can safely penetrate the plasma membrane and enter biological cells are potentially useful in high-resolution1,2,3,4,5,6 and high-throughput7,8 g...
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Selective and sensitive detection of metal ions by plasmonic resonance energy transfer-based nanospectroscopy
Highly selective and sensitive optical methods for the detection of metal ions have had a substantial impact on molecular biology1,2,3, environmental monitoring4,5,6,7,8,9,10 and other areas of research. Here we ...
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Quantized plasmon quenching dips nanospectroscopy via plasmon resonance energy transfer
We observed quantized plasmon quenching dips in resonant Rayleigh scattering spectra by plasmon resonance energy transfer (PRET) from a single nanoplasmonic particle to adsorbed biomolecules. This label-free b...
