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Article
Open AccessLarge-scale cross-ancestry genome-wide meta-analysis of serum urate
Hyperuricemia is an essential causal risk factor for gout and is associated with cardiometabolic diseases. Given the limited contribution of East Asian ancestry to genome-wide association studies of serum urat...
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Article
Interpersonal sensitivity and childhood trauma in patients with major depressive disorder, bipolar I, and II disorder
Childhood trauma and interpersonal sensitivity impact the development of mood disorders. In this study, we investigate the association between childhood trauma and interpersonal sensitivity in patients with mo...
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Article
Open AccessDeep learning model for distinguishing Mayo endoscopic subscore 0 and 1 in patients with ulcerative colitis
The aim of this study was to address the issue of differentiating between Mayo endoscopic subscore (MES) 0 and MES 1 using a deep learning model. A dataset of 492 ulcerative colitis (UC) patients who demonstra...
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Article
Open AccessMultimodal deep learning of fundus abnormalities and traditional risk factors for cardiovascular risk prediction
Cardiovascular disease (CVD), the leading cause of death globally, is associated with complicated underlying risk factors. We develop an artificial intelligence model to identify CVD using multimodal data, inc...
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Article
Open AccessAssociations between vascular risk factors and subsequent Alzheimer’s disease in older adults
The clinical guidelines related to the primary prevention of Alzheimer’s disease (AD) have focused on the management of vascular risk factors. However, the link between vascular risk factors and AD in older ad...
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Article
Open AccessRisk of domperidone induced severe ventricular arrhythmia
There has been controversy over the cardiovascular safety of domperidone, attributable to the lack of a well-designed study as well as inconsistent results. This study aimed to examine the risk of severe dompe...
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Article
Open AccessSubjective cognitive decline and subsequent dementia: a nationwide cohort study of 579,710 people aged 66 years in South Korea
Subjective cognitive decline (SCD) is a potential risk factor for dementia. We aimed to investigate the association between SCD and subsequent dementia in a nationwide population-based cohort in South Korea.
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Article
Open AccessEffectiveness of acid suppressants and other mucoprotective agents in reducing the risk of occult gastrointestinal bleeding in nonsteroidal anti-inflammatory drug users
Acid suppressants such as histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) are effective in preventing gastrointestinal (GI) bleeding in nonsteroidal anti-inflammatory drugs (NSAIDs) ...
