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  1. Article

    Open Access

    Similar survival after endoscopic submucosal dissection and esophagectomy in early esophageal cancer and synchronous or metachronous head and neck cancer

    Early-stage esophageal cancer is treated using endoscopic submucosal dissection and esophagectomy. Field cancerization in patients with early-stage esophageal cancer affects treatment outcomes and causes synch...

    Ruei-Ti Ke, Yu-Hsin Hsiao, Wei-Chen Tai, Shau-Hsuan Li in Journal of Cardiothoracic Surgery (2024)

  2. Article

    Open Access

    Real-world comparison of pembrolizumab and nivolumab in advanced hepatocellular carcinoma

    Nivolumab and pembrolizumab have not been directly compared in clinical trials, and the aim of this study is to investigate the efficacy and safety of nivolumab versus pembrolizumab in patients with advanced h...

    Yen-Hao Chen, Ching-Hua Tsai, Yen-Yang Chen, Chih-Chi Wang, **g-Houng Wang in BMC Cancer (2023)

  3. Article

    Open Access

    Low-dose nivolumab in advanced hepatocellular carcinoma

    The approved dose of nivolumab is 3 mg/kg or a flat dose of 240 mg for indications. There is no dose-response relationship for nivolumab; therefore, a low-dose regimen may be an option to reduce financial toxi...

    Yen-Hao Chen, Chih-Chi Wang, Yen-Yang Chen, **g-Houng Wang, Chao-Hung Hung in BMC Cancer (2022)

  4. Article

    Open Access

    Long-term survival after pulmonary metastasectomy in patients with esophageal squamous cell carcinoma with lung metastasis

    Esophageal squamous cell carcinoma with pulmonary metastasis has a poor prognosis, and the only treatment modality is systemic therapy such as chemotherapy. Previous studies showed that pulmonary metastasectom...

    Chien-Ming Lo, Kai-Hao Chuang, Hsing-Hua Lai, Yu Chen in Journal of Cardiothoracic Surgery (2022)

  5. Article

    Open Access

    Overexpression of UTX promotes tumor progression in Oral tongue squamous cell carcinoma patients receiving surgical resection: a case control study

    Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX) has been identified as a histone 3 lysine 27 (H3K27) demethylase and acted as a tumor suppressor gene or oncogenic function. The current ...

    Yen-Hao Chen, Chang-Han Chen, Chih-Yen Chien, Yan-Ye Su, Sheng-Dean Luo in BMC Cancer (2021)

  6. Article

    Open Access

    Improvement of surgical complications using single-lumen endotracheal tube intubation and artificial carbon dioxide pneumothorax in esophagectomy: a meta-analysis

    Esophageal cancer has a poor prognosis. Surgery is the main treatment but involves a high risk of complications. Some surgical strategies have tried to eliminate complications. Our meta-analysis tried to find ...

    Kai-Hao Chuang, Hsing-Hua Lai, Yu Chen, Li-Chun Chen in Journal of Cardiothoracic Surgery (2021)

  7. Article

    Open Access

    Chemotherapy in conjunction with traditional Chinese medicine for survival of patients with early female breast cancer: protocol for a non-randomized, single center prospective cohort study

    Chemotherapy after surgery for breast cancer plays a fundamental role in reducing the risk of distant and local recurrence. An increasing number of patients seek traditional Chinese medicine (TCM) during adjuv...

    Chien-Ting Liu, Yen-Hao Chen, Yu-Chuen Huang, Shih-Yu Chen, Ming-Yen Tsai in Trials (2019)

  8. No Access

    Article

    Recovery of heavy metals from waste printed circuit boards: statistical optimization of leaching and residue characterization

    Despite attempts to enhance the recycling of waste printed circuit boards (WPCBs), the simultaneous recovery of major metals of WPCBs using an efficient approach is still a great challenge. This study mainly c...

    Rasoul Khayyam Nekouei, Farshid Pahlevani in Environmental Science and Pollution Resear… (2019)

  9. Article

    Open Access

    An actin-binding protein ESPN is an independent prognosticator and regulates cell growth for esophageal squamous cell carcinoma

    ESPN (Espin), an actin filament-binding protein, plays an important role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializati...

    Shau-Hsuan Li, Hung-I Lu, Wan-Ting Huang, Yen-Hao Chen in Cancer Cell International (2018)

  10. Article

    Open Access

    Neck Lymph Node Metastasis as A Poor Prognostic Factor in Thoracic Esophageal Squamous Cell Carcinoma Patients Receiving Concurrent Chemoradiotherapy: A Propensity Score-Matched Analysis

    The present study investigated the clinical impact of neck lymph node (LN) metastasis in locally advanced inoperable thoracic esophageal squamous cell carcinoma (ESCC) patients who underwent concurrent chemora...

    Yen-Hao Chen, Hung-I Lu, Chien-Ming Lo, Yu-Ming Wang, Shang-Yu Chou in Scientific Reports (2018)

  11. Article

    Open Access

    The crucial role of blood VEGF kinetics in patients with locally advanced esophageal squamous cell carcinoma receiving curative concurrent chemoradiotherapy

    To evaluate the role of blood vascular endothelial growth factor (VEGF) kinetics in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT).

    Yen-Hao Chen, Hung-I Lu, Chien-Ming Lo, Yu-Ming Wang, Shang-Yu Chou in BMC Cancer (2018)

  12. No Access

    Chapter and Conference Paper

    Verifiable Privacy-Preserving Payment Mechanism for Smart Grids

    Smart grids have become a future trend due to the development of technology and increased energy demand and consumption. In smart grids, a user’s electricity consumption is recorded by their smart meters, and ...

    Chun-I Fan, Yi-Fan Tseng, Jheng-Jia Huang in Internet and Distributed Computing Systems (2018)

  13. Article

    Open Access

    Berberine regulates the protein expression of multiple tumorigenesis-related genes in hepatocellular carcinoma cell lines

    Hepatocellular carcinoma (HCC) is the seventh most common malignancy and the third leading cause of cancer-related death worldwide with an extremely grim prognosis. Berberine (BBR) has been found to inhibit pr...

    Tung-Yueh Chuang, Hsiao-Li Wu, Jie Min, Michael Diamond in Cancer Cell International (2017)

  14. Article

    Open Access

    Treatment Outcomes of Patients with Locally Advanced Synchronous Esophageal and Head/Neck Squamous Cell Carcinoma Receiving Curative Concurrent Chemoradiotherapy

    The present study investigated clinical outcomes and prognostic factors of patients with locally advanced synchronous esophageal squamous cell carcinoma (ESCC) and head/neck squamous cell carcinoma (HNSCC) rec...

    Yen-Hao Chen, Hung-I. Lu, Chih-Yen Chien, Chien-Ming Lo, Yu-Ming Wang in Scientific Reports (2017)

  15. Article

    Open Access

    A preliminary randomised controlled study of short-term Antrodia cinnamomea treatment combined with chemotherapy for patients with advanced cancer

    Antrodia cinnamomea (AC) is a popular medicinal mushroom in Taiwan that has been widely used for treatment of various cancers. Few clinical studies have reported its application and ef...

    Ming-Yen Tsai, Yu-Chiang Hung, Yen-Hao Chen in BMC Complementary and Alternative Medicine (2016)

  16. No Access

    Article

    Effects of annealing temperature on stress corrosion susceptibility of AA5083–H15 alloys

    Effects of annealing temperature on stress corrosion susceptibility of AA5083–H15 alloys were studied by annealing specimens at 150, 200, 250, 300, and 350 °C before sensitization. Nitric acid mass loss testin...

    Chun-Hung Yen, Chih-Ting Wu, Yen-Hao Chen, Sheng-Long Lee in Journal of Materials Research (2016)

  17. Article

    Open Access

    Betel nut chewing history is an independent prognosticator for smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil

    Smoking and betel nut chewing are well-known risk factors for head and neck squamous cell carcinoma (HNSCC). Smoking is also a strong prognosticator for patients with locally advanced HNSCC receiving induction...

    Yan-Ye Su, Chih-Yen Chien, Sheng-Dean Luo in World Journal of Surgical Oncology (2016)