4 Result(s)
within
Yejie Shi
Neurobiology
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Article
Open AccessTargeted ablation of signal transducer and activator of transduction 1 alleviates inflammation by microglia/macrophages and promotes long-term recovery after ischemic stroke
Brain microglia and macrophages (Mi/MΦ) can shift to a harmful or advantageous phenotype following an ischemic stroke. Identification of key molecules that regulate the transformation of resting Mi/MΦ could ai...
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Article
Open AccessMicroglia-specific deletion of histone deacetylase 3 promotes inflammation resolution, white matter integrity, and functional recovery in a mouse model of traumatic brain injury
Histone deacetylases (HDACs) are believed to exacerbate traumatic brain injury (TBI) based on studies using pan-HDAC inhibitors. However, the HDAC isoform responsible for the detrimental effects and the cell t...
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Chapter
Ion Transporters in Microglial Function: New Therapeutic Targets for Neuroinflammation in Ischemic Stroke?
Microglia are the macrophage immune cells in the CNS and monitor extracellular microenvironment in healthy brains. They can be rapidly activated under pathological conditions and move to a lesion site followin...
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Chapter
Na+/H+ Exchangers as Therapeutic Targets for Cerebral Ischemia
The Na+/H+ exchangers (NHE) are a family of membrane transporters that catalyzes the exchange of intracellular H+ with extracellular Na+ and plays a role in regulating intracellular pH and cell volume. Following ...
