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  1. No Access

    Article

    Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes

    Heterobifunctional chimeric degraders are a class of ligands that recruit target proteins to E3 ubiquitin ligases to drive compound-dependent protein degradation. Advancing from initial chemical tools, protein...

    James Schiemer, Reto Horst, Yilin Meng, Justin I. Montgomery… in Nature Chemical Biology (2021)

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    Article

    Detection of conformation types of cyclosporin retaining intramolecular hydrogen bonds by mass spectrometry

    Cyclosporin is a family of neutral cyclic undecapeptides widely used for the prevention of organ transplant rejection and controlling viral infection. The equilibrium of conformations assumed by cyclosporin A ...

    Suk-Joon Hyung, **dong Feng, Ye Che… in Analytical and Bioanalytical Chemistry (2014)