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  1. Article

    Open Access

    EPAC2 acts as a negative regulator in Matrigel-driven tubulogenesis of human microvascular endothelial cells

    Angiogenesis is physiologically essential for embryogenesis and development and reinitiated in adult animals during tissue growth and repair. Forming new vessels from the walls of existing vessels occurs as a ...

    Takayuki Ikeda, Yoshino Yoshitake, Yasuo Yoshitomi… in Scientific Reports (2021)

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    Article

    Regulation of soluble Flt-1 (VEGFR-1) production by hnRNP D and protein arginine methylation

    Soluble fms-like tyrosine kinase-1 (sFlt-1) functions as a potent inhibitor of angiogenesis by trap** vascular endothelial growth factor (VEGF). However, the precise regulatory mechanism of sFlt-1 production...

    Takayuki Ikeda, Yasuo Yoshitomi, Hidehito Saito… in Molecular and Cellular Biochemistry (2016)

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    Article

    Osteocytic cell necrosis is caused by a combination of glucocorticoid-induced Dickkopf-1 and hypoxia

    Osteonecrosis is a major glucocorticoid-induced complication in the orthopedics field. Despite the extensive researches, mechanisms underlining the glucocorticoid-induced osteonecrosis are largely unknown. Her...

    Shusuke Ueda, Toru Ichiseki, Yasuo Yoshitomi… in Medical Molecular Morphology (2015)