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Article
Open AccessLenalidomide and pomalidomide modulate hematopoietic cell expansion and differentiation in the presence of MSC
Cytopenia is a well-documented complication in the treatment of hematological malignancies with lenalidomide and pomalidomide. Although prior studies have highlighted direct effects on hematopoietic cells to e...
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Article
An association between a positive direct antiglobulin test and HLA-DR12 in COVID-19
SARS-CoV-2 infection has been reported to be associated with a positive direct antiglobulin test (DAT). In this study, an analysis of 40 consecutive coronavirus disease 2019 (COVID-19) cases from December 2020...
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Article
Open AccessCo-occurrence of relapsing polychondritis and autoimmune thyroid diseases
Relapsing polychondritis (RP) is a rare inflammatory disease characterized by recurrent inflammation and destruction of cartilaginous tissues. RP has characteristics of autoimmune disease and some reports have...
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Article
Anti-Fya-mediated delayed hemolytic transfusion reaction following emergency-release red blood cell transfusion: possible involvement of HLA-DRB1*04:03 in the Japanese population
A 43-year-old Japanese male, who had undergone open liver surgery for tumor resection, presented with decreased hemoglobin levels on Day 13 post-emergency-release transfusion of 16 units of Fy(a +) red blood c...
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Article
Impact of 2 Gy γ-irradiation on the hallmark characteristics of human bone marrow-derived MSCs
Two gray γ-irradiation is a widely employed basic module for total body irradiation (TBI) in allogeneic hematopoietic cell transplantation (HCT). The effects of γ-irradiation on hematopoietic and immune cells ...
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Article
Open AccessLong-term follow-up of patients with anti-cyclic citrullinated peptide antibody-positive connective tissue disease: a retrospective observational study including information on the HLA-DRB1 allele and citrullination dependency
The anti-cyclic citrullinated peptide (CCP) antibody is a diagnostic biomarker of rheumatoid arthritis (RA). However, some non-RA connective tissue disease (CTD) patients also test positive for the anti-CCP an...
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Article
Correction to: Menatetrenone facilitates hematopoietic cell generation in a manner that is dependent on human bone marrow mesenchymal stromal/stem cells
In the original publication of the article, the Figs. 4 C, F and 5 B, C were published with unexpected appearance of dots.
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Article
Menatetrenone facilitates hematopoietic cell generation in a manner that is dependent on human bone marrow mesenchymal stromal/stem cells
Vitamin K2 in the form of menatetrenone has clinical benefits for osteoporosis and cytopenia. Given the dominant role of mesenchymal-osteolineage cells in the regulation of hematopoiesis, we investigated wheth...
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Article
Successful granulocyte apheresis using medium molecular weight hydroxyethyl starch
Granulocyte transfusion (GTX) is a therapeutic option for severe bacterial or fungal infection in patients with sustained neutropenia after chemotherapy or stem cell transplantation. However, high molecular we...
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Article
Open AccessEffects of acute exposure to low-dose radiation on the characteristics of human bone marrow mesenchymal stromal/stem cells
In recent years, increasing attention has been paid to the effects of low-dose irradiation on human health. We examined whether low-dose irradiation affected the functions of mesenchymal stromal/stem cells (MS...
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Article
Erratum to: Bortezomib interferes with adhesion of B cell precursor acute lymphoblastic leukemia cells through SPARC up-regulation in human bone marrow mesenchymal stromal/stem cells
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Article
Bortezomib interferes with adhesion of B cell precursor acute lymphoblastic leukemia cells through SPARC up-regulation in human bone marrow mesenchymal stromal/stem cells
The poor prognosis of adults with B cell precursor acute lymphoblastic leukemia (BCP-ALL) is attributed to leukemia cells that are protected by the bone marrow (BM) microenvironment. In the present study, we e...
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Article
Open AccessPharmacological targeting of bone marrow mesenchymal stromal/stem cells for the treatment of hematological disorders
The therapeutic effects of mesenchymal stromal/stem cells (MSCs) are mainly based on three characteristics: immunomodulation, tissue regeneration, and hematopoietic support. Cell therapy using culture-expanded...
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Article
Human bone marrow mesenchymal stromal/stem cells: current clinical applications and potential for hematology
Human mesenchymal stromal/stem cells (MSCs) have capabilities for multi-differentiation, immunomodulation, and hematopoietic support. Based on these unique biological characteristics, human MSCs have been exte...
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Article
Guest editorial: Human mesenchymal stromal/stem cell (MSC)
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Article
Isolation of mesenchymal stromal/stem cells from small-volume umbilical cord blood units that do not qualify for the banking system
The clinical application of mesenchymal stromal/stem cells (MSCs) has been extensively explored. In this study, we examined the availability of freshly donated umbilical cord blood (UCB) units that do not qual...
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Article
Open AccessMesenchymal stem cells inhibit multiple myeloma cells via the Fas/Fas ligand pathway
Cell-based therapy represents a new frontier in the treatment of a wide variety of human diseases traditionally associated with morbidity outcomes, including those involving inflammation, autoimmunity, tissue ...
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Article
Methotrexate-associated lymphoplasmacytic lymphoma complicated with type 2 cryoglobulinemia
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Article
Breakthrough infection of trichosporon asahii in a patient with chronic lymphocytic leukemia
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Article
Effects of the Tyrosine Kinase Inhibitor Imatinib Mesylate on a Bcr-Abl-Positive Cell Line: Suppression of Autonomous Cell Growth but No Effect on Decreased Adhesive Property and Morphological Changes
Expression of the Bcr-Abl oncoprotein alters various aspects of hematopoietic cells. We investigated the effects of a Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate, on the proliferation, adhesive proper...
