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Article
Open AccessStructural basis of the substrate recognition and inhibition mechanism of Plasmodium falciparum nucleoside transporter PfENT1
By lacking de novo purine biosynthesis enzymes, Plasmodium falciparum requires purine nucleoside uptake from host cells. The indispensable nucleoside transporter ENT1 of P. falciparum facilitates nucleoside uptak...
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Article
Open AccessiTRAQ-based proteomic analysis of Deinococcus radiodurans in response to 12C6+ heavy ion irradiation
Deinococcus radiodurans (D. radiodurans) is best known for its extreme resistance to diverse environmental stress factors, including ionizing radiation (IR), ultraviolet (UV) irradiation, oxidative stress, and hi...
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Article
Open AccessNeuromyelitis optica spectrum disease coexisting with subacute combined degeneration: a case report
Subacute combined degeneration (SCD) is a demyelinating disease characterized by vitamin B12 deficiency related segmental degeneration of the dorsal or lateral columns of the spinal cord. However, few cases ha...
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Article
Open AccessClinical factors associated with cerebral autoregulation in ischemic stroke related to small artery occlusion
Existing data suggest that cerebral autoregulation (CA) varies among different subtypes of ischaemic stroke. CA is globally impaired in patients with small artery occlusion (SAO). However, the factors influenc...
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Article
Reconstruction of continuous brachial artery pressure wave from continuous finger arterial pressure in humans
Generalized transfer functions (GTFs) are available to compute the more relevant proximal blood pressure (BP) waveform from a more easily measured peripheral BP waveform. However, GTFs are based on the black b...
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Article
Numerical Simulation for Optimizing Injection – Production Parameters When Using Cyclic Steam Injection Plus Polymer Gel Flooding in An Offshore Heavy-Oil Field
We have conducted numerical simulation studies with the goal of improving recovery efficiency. Utilizing results obtained in pilot testing on the target reservoir, which was done previously using polymer gel f...
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Article
Endosomal pH-Responsive Polymer-Based Dual-Ligand-Modified Micellar Nanoparticles for Tumor Targeted Delivery and Facilitated Intracellular Release of Paclitaxel
The purpose of the present study was to design and fabricate endosomal pH-sensitive dual-ligand-modified micellar nanoparticles to achieve enhanced drug delivery to tumor cells and facilitated intracellular dr...
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Article
Open AccessPreparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol
Novel mixed polymeric micelles formed from biocompatible polymers, poly(ethylene glycol)-poly(lactide) (mPEG-PLA) and polyoxyethylene-660-12-hydroxy stearate (Solutol HS15), were fabricated and used as a nanoc...
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Article
Novel Mixed Polymeric Micelles for Enhancing Delivery of Anticancer Drug and Overcoming Multidrug Resistance in Tumor Cell Lines Simultaneously
To evaluate novel mixed polymeric micelles based on monomethoxy poly(ethylene glycol)-poly(D,L-lactic acid) (mPEG-PLA) and Pluronic L61 for delivery of paclitaxel (PTX) to circumvent unfavorable effects result...
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Article
GPU rendering for tiled multi-projector autostereoscopic display based on chromium
In this paper, a GPU-based high-resolution multiview rendering approach (HRMVRA) is presented and incorporated into Chromium, and then a tiled multi-projector autostereoscopic display system (TMPADS) based on ...
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Article
Development of Silymarin Self-Microemulsifying Drug Delivery System with Enhanced Oral Bioavailability
The objective of this work was to develop a self-microemulsifying drug delivery system (SMEDDS) for improving oral absorption of poorly water-soluble drug, silymarin. The pseudo-ternary phase diagrams were con...
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Article
Open AccessPreparation and Evaluation of Poly(Ethylene Glycol)–Poly(Lactide) Micelles as Nanocarriers for Oral Delivery of Cyclosporine A
A series of monomethoxy poly(ethylene glycol)–poly(lactide) (mPEG–PLA) diblock copolymers were designed according to polymer–drug compatibility and synthesized, and mPEG–PLA micelle was fabricated and used as ...
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Article
Open AccessSelf-Assembled Polymeric Micellar Nanoparticles as Nanocarriers for Poorly Soluble Anticancer Drug Ethaselen
A series of monomethoxy poly(ethylene glycol)-poly(lactide) (mPEG-PLA) diblock copolymers were synthesized, and mPEG-PLA micelle was fabricated and used as a nanocarrier for solubilization and delivery of a pr...
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Article
Molecular basis for antifreeze activity difference of two insect antifreeze protein isoforms
The insect spruce budworm (Choristoneura fumiferana) produces antifreeze protein (AFP) to assist in the protection of the over-wintering larval stage and contains multiple isoforms. Structures for two isoforms, k...
