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Article
Mitochondrial DNA mutation affects the pluripotency of embryonic stem cells with metabolism modulation
Mitochondria are the only organelles other than the nucleus harboring their DNA in mammalian cells. The mitochondrial DNA (mtDNA) mutation is the cause of many serious diseases, which still lack effective ther...
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Article
Open AccessNuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation
Pluripotent stem cells hold great promise in regenerative medicine and developmental biology studies. Mitochondrial metabolites, including tricarboxylic acid (TCA) cycle intermediates, have been reported to pl...
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Article
Correction to: MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening
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Article
MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening
Somatic cell reprogramming is an ideal model for studying epigenetic regulation as it undergoes dramatic chromatin remodeling. However, a role for phosphorylation signaling in chromatin protein modifications f...
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Article
Author Correction: Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation
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Article
Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation
Mitochondria, the only semiautonomous organelles in mammalian cells, possess a circular, double-stranded genome termed mitochondrial DNA (mtDNA). While nuclear genomic DNA compaction, chromatin compartmentaliz...
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Article
Author Correction: Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade
Somatic cell reprogramming provides insight into basic principles of cell fate determination, which remain poorly understood. Here we show that the transcription factor Glis1 induces multi-level epigenetic and...
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Article
A new sight: topology-dependent mitophagy
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Chapter and Conference Paper
The Research on E-Learning Interactive Technology Based on Discuz! Software
Based on the existing achievement analysis of the current E-learning, this dissertation introduces the interactive function of the Discuz! software, realizes the E-learning interactive study system based on th...
