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Article
Fluoxetine Successfully Treats Intracranial Enterovirus E18 Infection in a Patient with CD79a Deficiency Arising from Segmental Uniparental Disomy of Chromosome 19
The pre BCR complex plays a crucial role in B cell production, and its successful expression marks the B cell differentiation from the pro-B to pre-B. The CD79a and CD79b mutations, encoding Igα and Igβ respec...
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Article
Qualitative Immunoglobulin Deficiency Causes Bacterial Infections in Patients with STAT1 Gain-of-Function Mutations
STAT1 is a transduction and transcriptional regulator that functions within the classical JAK/STAT pathway. In addition to chronic mucocutaneous candidiasis, bacterial infections are a common occurrence in pat...
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Article
Open AccessStudy on environmental factors affecting the quality of codonopsis radix based on MaxEnt model and all-in-one functional factor
Owing to the increasing market demand of Codonopsis Radix, the cropper blindly cultivates to expand planting area for economic benefits, which seriously affects the quality of Codonopsis Radix. Therefore, this...
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Article
Genetic and Functional Identifying of Novel STAT1 Loss-of-Function Mutations in Patients with Diverse Clinical Phenotypes
Mutations in signal transducer and activator of transcription 1 (STAT1) cause a broad spectrum of disease phenotypes. Heterozygous STAT1 loss-of-function (LOF) mutations cause Mendelian susceptibility to mycobact...
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Article
Hyperactive PI3Kδ predisposes naive T cells to activation via aerobic glycolysis programs
Activated phosphoinositide 3-kinase δ syndrome (APDS) is an autosomal-dominant combined immunodeficiency disorder resulting from pathogenic gain-of-function (GOF) mutations in the PIK3CD gene. Patients with APDS ...
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Article
Thioredoxin-interacting protein: a critical link between autophagy disorders and pancreatic β-cell dysfunction
Thioredoxin-interacting protein (TXNIP) is a known important regulatory protein of islet β-cell biology and function, but the detailed mechanism is not clear. Autophagy plays a pivotal role in maintaining cell...
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Article
Improvement of loess characteristics using sodium alginate
Loess often has poor engineering properties due to its loose accumulation and strong collapsibility. Therefore, improvement of the soil is necessary to meet the needs of engineering. In the current work, the i...
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Article
E1021K Homozygous Mutation in PIK3CD Leads to Activated PI3K-Delta Syndrome 1
Activated PI3Kδ syndrome 1 is a primary immunodeficiency disease, usually caused by heterozygous mutations in PIK3CD. We aimed to identify the cause of homozygous mutation at c.G3061A (p.E1021K) in a patient and ...
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Article
Molecular and Phenotypic Characterization of Nine Patients with STAT1 GOF Mutations in China
Signal transducer and activator of transcription 1 (STAT1) is a transcription factor that mediates cellular responses to interferons (IFNs) and other cytokines and growth factors in diverse cell types. STAT1 gain...
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Article
Mycoplasma contamination affects cell characteristics and decreases the sensitivity of BV2 microglia to LPS stimulation
Mycoplasma is the most common contaminant and greatly affects host cells. The influence of mycoplasma on microglia cells remains unknown. Here, we investigated the influence of mycoplasma contamination on BV2 ...
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Article
Open AccessDamaged region filling and evaluation by symmetrical exemplar-based image inpainting for Thangka
Exemplar-based image inpainting, as proposed by Criminisi et al. (IEEE Trans Image Process 13(9):1200–1212, 2004), fills missing regions by using a similar exemplar. However, when the missing region is a uniqu...
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Article
Open AccessDuodenal GLP-1 signaling regulates hepatic glucose production through a PKC-δ-dependent neurocircuitry
Intestinal glucagon-like peptide-1 (GLP-1) is a hormone that stimulates insulin secretion and acts as a neuropeptide to control glucose homeostasis, but little is known whether intestinal GLP-1 has any effect ...
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Article
Open AccessNAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance
NAMPT has been suggested association with atherosclerosis and insulin resistance. However, the impact of NAMPT on atherosclerosis remained unknown. Therefore, the objective of this study was to use a NAMPT los...
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Article
Open AccessCirculating Zinc-α2-glycoprotein levels and Insulin Resistance in Polycystic Ovary Syndrome
The aim of study was to assess the relationship between zinc-α2-glycoprotein (ZAG) and androgen excess with insulin resistance in polycystic ovary syndrome (PCOS) women. 99 PCOS women and 100 healthy controls ...
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Article
B→O blood conversion
To maintain a constant supply of “universal blood type”, or group O red blood cells, has benefit in specialized transfusion condition. In this study, α-galactosidase cDNA was cloned from Catimor coffee bean gr...
