240 Result(s)
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Article
Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1
DNA methylation is a key epigenetic process and the faithful maintenance of DNA methylation patterns is essential to the wellbeing of mammalian cells. This means that cells need a mechanism to identify the par...
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Open AccessInterplay between the Westerlies and Asian monsoon recorded in Lake Qinghai sediments since 32 ka
Two atmospheric circulation systems, the mid-latitude Westerlies and the Asian summer monsoon (ASM), play key roles in northern-hemisphere climatic changes. However, the variability of the Westerlies in Asia a...
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Article
Biological features of novel avian influenza A (H7N9) virus
An initial characterization of the receptor-binding properties of the novel avian influenza A (H7N9) shows that the virus has acquired the ability to bind human receptors while retaining the ability to bind av...
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Open AccessQuantitative epigenetic co-variation in CpG islands and co-regulation of developmental genes
The genome-wide variation of multiple epigenetic modifications in CpG islands (CGIs) and the interactions between them are of great interest. Here, we optimized an entropy-based strategy to quantify variation ...
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Open AccessNetwork Analysis Reveals Functional Cross-links between Disease and Inflammation Genes
Connections between inflammation and diseases are suggested important in understanding the genetic mechanisms of diseases. However, studies on the functional cross-links between inflammation and disease genes ...
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Open AccessCyclic precipitation variation on the western Loess Plateau of China during the past four centuries
Precipitation variation on the Loess Plateau (LP) of China is not only important for rain-fed agriculture in this environmentally sensitive region, but also critical for the water and life securities over the ...
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Open AccessDiminished serum repetin levels in patients with schizophrenia and bipolar disorder
Repetin (RPTN) protein is a member of S100 family and is known to be expressed in the normal epidermis. Here we show that RPTN is ubiquitously expressed in both mouse and human brain, with relatively high leve...
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Open AccessWhole-genome sequencing reveals that mutations in myosin-5 confer resistance to the fungicide phenamacril in Fusarium graminearum
To determine the mechanism of resistance to the fungicide phenamacril (JS399-19) in Fusarium graminearum, the causal agent of Fusarium head blight, we sequenced and annotated the genome of the resistant strain YP...
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Open AccessA biopolymer-like metal enabled hybrid material with exceptional mechanical prowess
The design principles for naturally occurring biological materials have inspired us to develop next-generation engineering materials with remarkable performance. Nacre, commonly referred to as nature's armor, ...
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Open AccessChromatin modifications and genomic contexts linked to dynamic DNA methylation patterns across human cell types
DNA methylation is related closely to sequence contexts and chromatin modifications; however, their potential differences in different genomic regions across cell types remain largely unexplored. We used publi...
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The amino-terminal structure of human fragile X mental retardation protein obtained using precipitant-immobilized imprinted polymers
Flexibility is an intrinsic property of proteins and essential for their biological functions. However, because of structural flexibility, obtaining high-quality crystals of proteins with heterogeneous conform...
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Article
Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression
Pancreatic cancer (PC) is a particularly lethal form of cancer with high potential for metastasis to distant organs. Disruption of cell polarity is a hallmark of advanced epithelial tumours. Here we show that ...
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Dissemination, divergence and establishment of H7N9 influenza viruses in China
Influenza surveillance over 15 cities across 5 provinces in China from October 2013 to July 2014 shows that the virus has diverged into distinct clades, becoming established in chickens and also disseminating ...
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Open AccessPlasmonic Toroidal Dipolar Response under Radially Polarized Excitation
Plasmonic toroidal resonance has attracted growing interests because of its low loss electromagnetic properties and potential high sensitive nanophotonic applications. However, the realization in a metamateria...
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Open AccessThe Effects of Combined Treatment with Naringin and Treadmill Exercise on Osteoporosis in Ovariectomized Rats
Osteoporosis is a disease characterized by low bone mass and progressive destruction of bone microstructure, resulting in increased the risk of fracture. Previous studies have demonstrated the effect of naring...
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Open AccessESEA: Discovering the Dysregulated Pathways based on Edge Set Enrichment Analysis
Pathway analyses are playing an increasingly important role in understanding biological mechanism, cellular function and disease states. Current pathway-identification methods generally focus on only the chang...
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Open AccessA Chinese cave links climate change, social impacts and human adaptation over the last 500 years
The collapse of some pre-historical and historical cultures, including Chinese dynasties were presumably linked to widespread droughts, on the basis of synchronicities of societal crises and proxy-based climat...
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Open AccessTopologically inferring pathway activity toward precise cancer classification via integrating genomic and metabolomic data: prostate cancer as a case
Precise cancer classification is a central challenge in clinical cancer research such as diagnosis, prognosis and metastasis prediction. Most existing cancer classification methods based on gene or metabolite ...
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Open AccessGenetic association of RIT2 rs12456492 polymorphism and Parkinson’s disease susceptibility in Asian populations: a meta-analysis
Recent studies investigating the association of the Ras-like without CAAX 2 (RIT2) polymorphism, rs12456492, with Parkinson’s disease (PD) are controversial. We performed a meta-analysis to study the association ...
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Open AccessA new nanoscale metastable iron phase in carbon steels
Metastable ω phase is common in body-centred cubic (bcc) metals and alloys, including high-alloying steels. Recent theoretical calculations also suggest that the ω structure may act as an intermediate phase fo...
