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Article
Mechanical Analysis of Rock Tunnels Reinforced by Grouted Rockbolts Considering the Blasting Damage Effect
Tunnelling using drilling and blasting method inevitably disturbs the surrounding rock and induces a blasting damaged zone around the tunnel. Conventional mechanical analyses assume that the entire ground is d...
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Article
Open AccessMitochondrial oxidative damage reprograms lipid metabolism of renal tubular epithelial cells in the diabetic kidney
The functional and structural changes in the proximal tubule play an important role in the occurrence and development of diabetic kidney disease (DKD). Diabetes-induced metabolic changes, including lipid metab...
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Article
Support Countermeasures for Large Deformation in a Deep Tunnel in Layered Shale with High Geostresses
Large deformation is a crucial factor in deep-buried tunnels constructed through soft rocks with a high geostress. Taking the deep-buried Baozhen tunnel through layered shale as an example, this study investig...
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Article
Open AccessCD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys
Tubulointerstitial inflammation plays a key role in the pathogenesis of diabetic nephropathy (DN). Interleukin-1β (IL-1β) is the key proinflammatory cytokine associated with tubulointerstitial inflammation. Th...
